PDF(Pubmed)
Abstract：
While strides in cancer treatment continue to advance, the enduring challenges posed by cancer metastasis and recurrence persist as formidable contributors to the elevated mortality rates observed in cancer patients. Among the multifaceted factors implicated in tumor recurrence and metastasis, cancer stem cells (CSCs) emerge as noteworthy entities due to their inherent resistance to conventional therapies and heightened invasive capacities. Characterized by their notable abilities for self-renewal, differentiation, and initiation of tumorigenesis, the eradication of CSCs emerges as a paramount objective. Recent investigations increasingly emphasize the pivotal role of post-translational protein modifications (PTMs) in governing the self-renewal and replication capabilities of CSCs. This review accentuates the critical significance of several prevalent PTMs and the intricate interplay of PTM crosstalk in regulating CSC behavior. Furthermore, it posits that the manipulation of PTMs may offer a novel avenue for targeting and eliminating CSC populations, presenting a compelling perspective on cancer therapeutics with substantial potential for future applications.
摘要：
虽然癌症治疗的进展仍在继续，癌症转移和复发带来的持久挑战仍然是癌症患者死亡率升高的强大因素.在与肿瘤复发和转移有关的多方面因素中，癌症干细胞（CSC）由于其对传统疗法的固有抵抗力和增强的侵袭能力而成为值得注意的实体。以他们显著的自我更新能力为特征，分化,和肿瘤发生的开始，根除CSC成为首要目标。最近的研究越来越强调翻译后蛋白质修饰（PTM）在控制CSC的自我更新和复制能力中的关键作用。这篇评论强调了几种流行的PTM的关键意义以及PTM串扰在调节CSC行为中的复杂相互作用。此外，它认为PTM的操纵可能为靶向和消除CSC人群提供了一种新的途径，对癌症治疗提出了令人信服的观点，具有未来应用的巨大潜力。
