PDF(Pubmed)
Abstract：
Notch signaling pathway is activated abnormally in solid and hematological tumors, which perform essential functions in cell differentiation, survival, proliferation, and angiogenesis. The activation of Notch signaling and communication among Notch and other oncogenic pathways heighten malignancy aggressiveness. Thus, targeting Notch signaling offers opportunities for improved survival and reduced disease incidence. Already, most attention has been given to its role in the cancer cells. Recent research shows that natural bioactive compounds can change signaling molecules that are linked to or interact with the Notch pathways. This suggests that there may be a link between Notch activation and the growth of tumors. Here, we sum up the natural bioactive compounds that possess inhibitory effects on human cancers by impeding the Notch pathway and preventing Notch crosstalk with other oncogenic pathways, which provoke further study of these natural products to derive rational therapeutic regimens for the treatment of cancer and develop novel anticancer drugs. This review revealed Notch as a highly challenging but promising target in oncology.
摘要：
Notch信号通路在实体和血液肿瘤中异常激活，在细胞分化中发挥基本功能，生存,扩散,和血管生成。Notch信号的激活以及Notch和其他致癌途径之间的通讯增强了恶性肿瘤的侵袭性。因此，靶向Notch信号提供了改善生存率和降低疾病发生率的机会.已经,它在癌细胞中的作用受到了最大的关注。最近的研究表明，天然生物活性化合物可以改变与Notch通路连接或相互作用的信号分子。这表明Notch激活与肿瘤生长之间可能存在联系。这里,我们总结了通过阻断Notch途径和防止Notch与其他致癌途径的串扰对人类癌症具有抑制作用的天然生物活性化合物，这激发了对这些天然产物的进一步研究，以得出治疗癌症的合理治疗方案并开发新的抗癌药物。这篇综述揭示了Notch是肿瘤学中一个极具挑战性但有前途的靶标。
