PDF(Pubmed)
Abstract：
Vitamins are dietary components necessary for cellular metabolic balance, especially redox homeostasis; deficient or excessive supply may give rise to symptoms of psychiatric disorders. Exploring the nutritional and metabolic pathways of vitamins could contribute to uncovering the underlying pathogenesis of ferroptosis-associated diseases. This mini-review aims to provide insights into vitamins closely linked to the regulation of ferroptosis from the perspective of cellular reactive oxygen species biology. The mainstream reprogramming mechanisms of ferroptosis are overviewed, focusing on unique biological processes of iron metabolism, lipid metabolism, and amino acid metabolism. Moreover, recent breakthroughs in therapeutic interventions targeting ferroptosis via fully utilizing vitamin-based pharmacological tools were overviewed, covering vitamins (B, C, E, and K). Finally, mechanism insight related to vitamin-associated nutrient signaling was provided, highlighting the pharmacological benefits of metabolically reprogramming ferroptosis-associated diseases.
摘要：
维生素是细胞代谢平衡所必需的饮食成分，尤其是氧化还原稳态；供应不足或过量可能会引起精神疾病的症状。探索维生素的营养和代谢途径可能有助于揭示铁凋亡相关疾病的潜在发病机理。这篇小型综述旨在从细胞活性氧生物学的角度提供与铁凋亡调节密切相关的维生素的见解。概述了铁凋亡的主流重编程机制，专注于铁代谢的独特生物过程，脂质代谢，和氨基酸代谢。此外，概述了通过充分利用基于维生素的药理学工具来针对铁性凋亡的治疗干预措施的最新突破，涵盖维生素（B，C,E,和K）。最后,提供了与维生素相关的营养信号相关的机制见解，强调代谢重编程铁凋亡相关疾病的药理学益处。
