PDF(Pubmed)
Abstract：
UNASSIGNED: Pregnancy in women diagnosed with Type-1 diabetes mellitus poses a higher risk of experiencing complications related to the health of the fetus, the mother, and the newborn, along with potential obstetric issues. The objective of this study was to examine the maternal and fetal outcomes, as well as complications faced by pregnant women with type-1 diabetes, and to identify potential preventable factors.
UNASSIGNED: This retrospective cohort study, conducted at Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University, Karachi, Pakistan (January 2022 - January 2023), focused on registered pregnancies of women with Type-1 diabetes. A predesigned questionnaire recorded demographic information, diabetes and obstetric history, clinical details, treatment specifics, maternal, perinatal, and neonatal outcomes.
UNASSIGNED: This study included 100 women with pre-existing Type-1 diabetes (mean age: 15.11 ± 5.64 years at diabetes diagnosis). Of these, 72% reported unplanned pregnancies, with a mean HbA1C at conception 8.29%. Median gestational age at delivery was 32.15 ± 10.82 weeks. Delivery outcomes included 40% normal vaginal deliveries and 60% C-sections (9% emergency, 51% elective). Stillbirths occurred in 14 cases, while 16 women experienced one miscarriage, seven had two, and 10 had three miscarriages. Glycemic targets (fasting) were achieved in 55 women, and post-meal targets only in 29, whereas, neonatal complications included hypoglycemia in 13 and low birth weight in 12 neonates.
UNASSIGNED: The high frequency of unplanned pregnancies and cesarean sections along with poor management of pre-pregnancy care and poor glycemic control results in compromised maternal and perinatal outcomes in this high-risk group.
UNASSIGNED: This retrospective cohort study, conducted at Baqai Institute of Diabetology and Endocrinology (BIDE), Baqai Medical University, Karachi, Pakistan (January 2022 - January 2023), focused on registered pregnancies of women with Type-1 diabetes. A predesigned questionnaire recorded demographic information, diabetes and obstetric history, clinical details, treatment specifics, maternal, perinatal, and neonatal outcomes.
UNASSIGNED: This study included 100 women with pre-existing Type-1 diabetes (mean age: 15.11 ± 5.64 years at diabetes diagnosis). Of these, 72% reported unplanned pregnancies, with a mean HbA1C at conception 8.29%. Median gestational age at delivery was 32.15 ± 10.82 weeks. Delivery outcomes included 40% normal vaginal deliveries and 60% C-sections (9% emergency, 51% elective). Stillbirths occurred in 14 cases, while 16 women experienced one miscarriage, seven had two, and 10 had three miscarriages. Glycemic targets (fasting) were achieved in 55 women, and post-meal targets only in 29, whereas, neonatal complications included hypoglycemia in 13 and low birth weight in 12 neonates.
UNASSIGNED: The high frequency of unplanned pregnancies and cesarean sections along with poor management of pre-pregnancy care and poor glycemic control results in compromised maternal and perinatal outcomes in this high-risk group.
摘要：
■被诊断为1型糖尿病的女性怀孕会增加与胎儿健康相关的并发症的风险，母亲,新生儿，以及潜在的产科问题。这项研究的目的是检查母体和胎儿的结局，以及1型糖尿病孕妇面临的并发症，并确定潜在的可预防因素。
■这项回顾性队列研究，在Baqai糖尿病和内分泌学研究所（BIDE）进行，巴凯医科大学,卡拉奇,巴基斯坦（2022年1月-2023年1月），重点关注1型糖尿病妇女的登记怀孕情况。预先设计的问卷记录了人口统计信息，糖尿病和产科史，临床细节，治疗细节，母性,围产期,和新生儿结局。
■这项研究包括100名预先存在1型糖尿病的女性（平均年龄：15.11±5.64岁的糖尿病诊断）。其中,72%的人报告了意外怀孕，受孕时平均HbA1C为8.29%。分娩时的中位胎龄为32.15±10.82周。分娩结果包括40%正常阴道分娩和60%剖腹产(9%急诊，51%选修)。14例发生死胎，16名妇女经历了一次流产，七个有两个，10人流产了3次.55名女性实现了血糖目标（禁食），和餐后目标只有29，而，新生儿并发症包括13例低血糖和12例新生儿低出生体重。
意外妊娠和剖宫产的频率高，孕前护理管理不善，血糖控制不佳，导致这一高危人群的孕产妇和围产期结局受损。
■这项回顾性队列研究，在Baqai糖尿病和内分泌学研究所（BIDE）进行，巴凯医科大学,卡拉奇,巴基斯坦（2022年1月-2023年1月），重点关注1型糖尿病妇女的登记怀孕情况。预先设计的问卷记录了人口统计信息，糖尿病和产科史，临床细节，治疗细节，母性,围产期,和新生儿结局。
■这项研究包括100名预先存在1型糖尿病的女性（平均年龄：15.11±5.64岁的糖尿病诊断）。其中,72%的人报告了意外怀孕，受孕时平均HbA1C为8.29%。分娩时的中位胎龄为32.15±10.82周。分娩结果包括40%正常阴道分娩和60%剖腹产(9%急诊，51%选修)。14例发生死胎，16名妇女经历了一次流产，七个有两个，10人流产了3次.55名女性实现了血糖目标（禁食），和餐后目标只有29，而，新生儿并发症包括13例低血糖和12例新生儿低出生体重。
意外妊娠和剖宫产的频率高，孕前护理管理不善，血糖控制不佳，导致这一高危人群的孕产妇和围产期结局受损。
