PDF(Pubmed)
Abstract：
The global incidence of cancer is increasing, with estimates suggesting that there will be 26 million new cases and 17 million deaths per year by 2030. Cancer stem cells (CSCs) and extracellular vesicles (EVs) are key to the resistance and advancement of cancer. They play a crucial role in tumor dynamics and resistance to therapy. CSCs, initially discovered in acute myeloid leukemia, are well-known for their involvement in tumor initiation, progression, and relapse, mostly because of their distinct characteristics, such as resistance to drugs and the ability to self-renew. EVs, which include exosomes, microvesicles, and apoptotic bodies, play a vital role in facilitating communication between cells within the tumor microenvironment (TME). They have a significant impact on cellular behaviors and contribute to genetic and epigenetic changes. This paper analyzes the mutually beneficial association between CSCs and EVs, emphasizing their role in promoting tumor spread and developing resistance mechanisms. This review aims to investigate the interaction between these entities in order to discover new approaches for attacking the complex machinery of cancer cells. It highlights the significance of CSCs and EVs as crucial targets in the advancement of novel cancer treatments, which helps stimulate additional research, promote progress in ideas for cancer treatment, and provide renewed optimism in the effort to reduce the burden of cancer.
摘要：
全球癌症发病率不断上升,据估计，到2030年，每年将有2600万新病例和1700万人死亡。癌症干细胞（CSC）和细胞外囊泡（EV）是癌症抵抗和发展的关键。它们在肿瘤动力学和对治疗的抵抗中起着至关重要的作用。CSCs,最初在急性髓系白血病中发现，以参与肿瘤启动而闻名，programming,和复发，主要是因为它们独特的特点，例如对药物的抗性和自我更新的能力。电动汽车,其中包括外泌体，微泡,和凋亡体，在促进肿瘤微环境（TME）内细胞之间的通讯中起着至关重要的作用。它们对细胞行为有重大影响，并有助于遗传和表观遗传变化。本文分析了CSCs与电动汽车之间的互利联系，强调它们在促进肿瘤扩散和发展耐药机制中的作用。这篇综述旨在研究这些实体之间的相互作用，以发现攻击癌细胞复杂机制的新方法。它强调了CSC和EV作为新型癌症治疗进展中的关键靶标的重要性。这有助于刺激更多的研究，促进癌症治疗理念的进步，并为减轻癌症负担的努力提供新的乐观态度。
