PDF(Pubmed)
Abstract：
UNASSIGNED: Diabetes in pregnancy is associated with impaired offspring cardiac function. The objective of this systematic review was to determine the effect of diabetes in pregnancy on cardiac function in the offspring measured by echocardiography.
UNASSIGNED: PubMed, Embase, Cochrane CENTRAL and Web of Science databases were searched from 1992 to June 27, 2023. Studies reporting offspring (age < 18 years) cardiac function by echocardiography compared between any type of diabetes in pregnancy and healthy control pregnancies were included. Study selection, quality assessment and risk of bias was independently performed by two reviewers. Meta-analyses was performed where possible.
UNASSIGNED: Thirty-one observational studies were included 1,679 cases and 2,694 controls. In the first week of life (23 studies, n = 2,663), intraventricular septum diastolic diameter (hypertrophy) was increased, while myocardial performance index (global function) and LV E/A-ratio (diastolic function) were decreased. No difference was found for left ventricular ejection fraction (systolic function). At 1-6 months (4 studies, n = 454) studies found hypertrophy, and decreased global function, but no difference in systolic or diastolic function. At 1-8 years (7 studies, n = 1,609) no difference was found. The available data did not allow for sub-analysis based on the type of diabetes, treatment, or glycemic control.
UNASSIGNED: Diabetes in pregnancy is associated with cardiac hypertrophy and impaired global cardiac function in infants up to six months old. The few studies reporting on older children found no difference in the parameters investigated. Longitudinal studies employing more advanced echocardiographic measures or MRI are needed to evaluate consequences for long-term cardiac health.
UNASSIGNED: https://www.crd.york.ac.uk/, identifier (CRD42022312471).
UNASSIGNED: PubMed, Embase, Cochrane CENTRAL and Web of Science databases were searched from 1992 to June 27, 2023. Studies reporting offspring (age < 18 years) cardiac function by echocardiography compared between any type of diabetes in pregnancy and healthy control pregnancies were included. Study selection, quality assessment and risk of bias was independently performed by two reviewers. Meta-analyses was performed where possible.
UNASSIGNED: Thirty-one observational studies were included 1,679 cases and 2,694 controls. In the first week of life (23 studies, n = 2,663), intraventricular septum diastolic diameter (hypertrophy) was increased, while myocardial performance index (global function) and LV E/A-ratio (diastolic function) were decreased. No difference was found for left ventricular ejection fraction (systolic function). At 1-6 months (4 studies, n = 454) studies found hypertrophy, and decreased global function, but no difference in systolic or diastolic function. At 1-8 years (7 studies, n = 1,609) no difference was found. The available data did not allow for sub-analysis based on the type of diabetes, treatment, or glycemic control.
UNASSIGNED: Diabetes in pregnancy is associated with cardiac hypertrophy and impaired global cardiac function in infants up to six months old. The few studies reporting on older children found no difference in the parameters investigated. Longitudinal studies employing more advanced echocardiographic measures or MRI are needed to evaluate consequences for long-term cardiac health.
UNASSIGNED: https://www.crd.york.ac.uk/, identifier (CRD42022312471).
摘要：
■妊娠期糖尿病与后代心脏功能受损有关。这项系统评价的目的是确定妊娠糖尿病对超声心动图测量的后代心脏功能的影响。
■PubMed,Embase,从1992年到2023年6月27日搜索了CochraneCENTRAL和WebofScience数据库。包括通过超声心动图报告子代（年龄<18岁）心脏功能的研究，比较了妊娠中任何类型的糖尿病和健康对照妊娠。研究选择，质量评估和偏倚风险由两名评审员独立进行.在可能的情况下进行荟萃分析。
■31项观察性研究包括1,679例病例和2,694例对照。在生命的第一周（23项研究，n=2,663)，室间隔舒张直径（肥大）增加，而心肌性能指数（整体功能）和LVE/A比（舒张功能）降低。左心室射血分数（收缩功能）无差异。在1-6个月（4项研究，n=454）研究发现肥大，全球功能下降，但收缩或舒张功能没有差异.在1-8年(7项研究，n=1,609)没有发现差异。现有数据不允许根据糖尿病类型进行亚分析，治疗,或血糖控制。
妊娠糖尿病与6个月以下婴儿的心脏肥大和整体心脏功能受损有关。少数报道年龄较大儿童的研究发现，所调查的参数没有差异。需要采用更先进的超声心动图或MRI的纵向研究来评估长期心脏健康的后果。
■https://www.crd.约克。AC.英国/,标识符(CRD42022312471)。
■PubMed,Embase,从1992年到2023年6月27日搜索了CochraneCENTRAL和WebofScience数据库。包括通过超声心动图报告子代（年龄<18岁）心脏功能的研究，比较了妊娠中任何类型的糖尿病和健康对照妊娠。研究选择，质量评估和偏倚风险由两名评审员独立进行.在可能的情况下进行荟萃分析。
■31项观察性研究包括1,679例病例和2,694例对照。在生命的第一周（23项研究，n=2,663)，室间隔舒张直径（肥大）增加，而心肌性能指数（整体功能）和LVE/A比（舒张功能）降低。左心室射血分数（收缩功能）无差异。在1-6个月（4项研究，n=454）研究发现肥大，全球功能下降，但收缩或舒张功能没有差异.在1-8年(7项研究，n=1,609)没有发现差异。现有数据不允许根据糖尿病类型进行亚分析，治疗,或血糖控制。
妊娠糖尿病与6个月以下婴儿的心脏肥大和整体心脏功能受损有关。少数报道年龄较大儿童的研究发现，所调查的参数没有差异。需要采用更先进的超声心动图或MRI的纵向研究来评估长期心脏健康的后果。
■https://www.crd.约克。AC.英国/,标识符(CRD42022312471)。
