PDF(Pubmed)
Abstract：
UNASSIGNED: To compare the structural anatomy of the anterior segment in pediatric Trisomy 21 (T21) subjects with and without cataracts to age-matched controls.
UNASSIGNED: Prospective case-control study.
UNASSIGNED: 40 subjects (57 eyes) age 0-25 years old (9.1 ± 10.6 years).
UNASSIGNED: This prospective case-control study evaluated anterior segment measurements from ultrasound biomicroscopy (UBM) imaging on 342 images.
UNASSIGNED: Among persons with T21 cataract, the iris was significantly thinner than T21 individuals without cataract (0.28 vs 0.32 mm, p = 0.0181). T21/cataract subjects also had significantly thinner lenses than subjects without cataract, regardless of whether they have T21 or are controls (3.1 mm vs 3.5 mm, p = 0.0074).Thinner lens (<3.5 mm) was insignificantly associated with increased odds of cataract (OR = 9.5 [0.872,104], p = 0.065). Thinner iris (<0.32 mm) was associated with increased odds of cataract (OR = 8.4 [1.188, 59.273], p = 0.033).
UNASSIGNED: These findings support the hypothesis that subtle quantitative anatomic variants are present in the anterior eye of individuals with T21. Specific anatomic variants are unique to the presence of cataract among subjects with T21.
UNASSIGNED: Prospective case-control study.
UNASSIGNED: 40 subjects (57 eyes) age 0-25 years old (9.1 ± 10.6 years).
UNASSIGNED: This prospective case-control study evaluated anterior segment measurements from ultrasound biomicroscopy (UBM) imaging on 342 images.
UNASSIGNED: Among persons with T21 cataract, the iris was significantly thinner than T21 individuals without cataract (0.28 vs 0.32 mm, p = 0.0181). T21/cataract subjects also had significantly thinner lenses than subjects without cataract, regardless of whether they have T21 or are controls (3.1 mm vs 3.5 mm, p = 0.0074).Thinner lens (<3.5 mm) was insignificantly associated with increased odds of cataract (OR = 9.5 [0.872,104], p = 0.065). Thinner iris (<0.32 mm) was associated with increased odds of cataract (OR = 8.4 [1.188, 59.273], p = 0.033).
UNASSIGNED: These findings support the hypothesis that subtle quantitative anatomic variants are present in the anterior eye of individuals with T21. Specific anatomic variants are unique to the presence of cataract among subjects with T21.
摘要：
■比较患有和不患有白内障的小儿21三体（T21）受试者与年龄匹配的对照组的眼前节的结构解剖。
■前瞻性病例对照研究。
■40名受试者（57眼），年龄0-25岁（9.1±10.6岁）。
■这项前瞻性病例对照研究在342张图像上评估了超声生物显微镜（UBM）成像的眼前节测量结果。
■在T21白内障患者中，虹膜明显比没有白内障的T21个体薄（0.28vs0.32mm，p=0.0181)。T21/白内障受试者的晶状体也比没有白内障的受试者明显薄，无论他们是否有T21或控制(3.1毫米vs3.5毫米，p=0.0074）。较薄的晶状体(<3.5mm)与白内障几率增加无显著相关(OR=9.5[0.872,104],p=0.065)。较薄的虹膜(<0.32mm)与白内障几率增加相关(OR=8.4[1.188,59.273],p=0.033)。
■这些发现支持以下假设：T21患者的前眼中存在细微的定量解剖变异。特定的解剖变体对于患有T21的受试者中白内障的存在是独特的。
■前瞻性病例对照研究。
■40名受试者（57眼），年龄0-25岁（9.1±10.6岁）。
■这项前瞻性病例对照研究在342张图像上评估了超声生物显微镜（UBM）成像的眼前节测量结果。
■在T21白内障患者中，虹膜明显比没有白内障的T21个体薄（0.28vs0.32mm，p=0.0181)。T21/白内障受试者的晶状体也比没有白内障的受试者明显薄，无论他们是否有T21或控制(3.1毫米vs3.5毫米，p=0.0074）。较薄的晶状体(<3.5mm)与白内障几率增加无显著相关(OR=9.5[0.872,104],p=0.065)。较薄的虹膜(<0.32mm)与白内障几率增加相关(OR=8.4[1.188,59.273],p=0.033)。
■这些发现支持以下假设：T21患者的前眼中存在细微的定量解剖变异。特定的解剖变体对于患有T21的受试者中白内障的存在是独特的。
