PDF(Pubmed)
Abstract：
Compared to the rapidly growing literature on transcranial electrical stimulation (tES) in humans, research into the mechanisms underlying neuromodulation by tES using in-vivo animal models is growing but still relatively rare. Such research, however, is key to overcoming experimental limitations in humans and essential to build a detailed understanding of the in-vivo consequences of tES that can ultimately lead to development of targeted and effective therapeutic applications of noninvasive brain stimulation. The sheer difference in scale and geometry between animal models and the human brain contributes to the complexity of designing and interpreting animal studies. Here we extend previous approaches to model intracranial electric fields to generate predictions that can be tested with in-vivo intracranial recordings. Although the toolbox has general applicability and could be used to predict intracranial fields for any tES study using mice, we illustrate its usage by comparing fields in a high-density multi-electrode montage with a more traditional two electrode montage. Our simulations show that both montages can produce strong focal homogeneous electric fields in targeted areas. However, the high-density montage produces a field that is more perpendicular to the visual cortical surface, which is expected to result in larger changes in neuronal excitability.
摘要：
与快速增长的人类经颅电刺激（tES）文献相比，使用体内动物模型对tES神经调节的潜在机制的研究正在增长，但仍然相对罕见。这样的研究,然而,是克服人类实验局限性的关键，并且对于详细了解tES的体内后果至关重要，这最终可以导致开发非侵入性脑刺激的靶向有效治疗应用。动物模型和人脑之间的规模和几何形状的巨大差异导致了设计和解释动物研究的复杂性。在这里，我们扩展了先前的方法来模拟颅内电场，以生成可以通过体内颅内记录进行测试的预测。尽管该工具箱具有普遍适用性，可用于预测任何使用小鼠的tES研究的颅内场，我们通过比较高密度多电极蒙太奇与更传统的两个电极蒙太奇中的场来说明其用法。我们的模拟表明，两种蒙太奇都可以在目标区域产生强大的焦均匀电场。然而,高密度蒙太奇产生一个更垂直于视觉皮层表面的场，这预计会导致神经元兴奋性的更大变化。
■EFMouse是一部小说，开源,基于Matlab的小鼠大脑电场模拟器EFMouse量化了Allen小鼠脑图谱区域的视野焦点和均匀性。可以用两个或五个电极蒙太奇产生局灶性和强烈的刺激。具有腰椎返回的高密度蒙太奇会产生垂直于皮质表面的场。
■EFMouse是一部小说，开源,基于Matlab的小鼠大脑电场模拟器EFMouse量化了Allen小鼠脑图谱区域的视野焦点和均匀性。可以用两个或五个电极蒙太奇产生局灶性和强烈的刺激。具有腰椎返回的高密度蒙太奇会产生垂直于皮质表面的场。
