PDF(Pubmed)
Abstract：
UNASSIGNED: The Geriatric Nutritional Risk Index (GNRI) is a straightforward and objective tool for nutritional screening in older patients and has been demonstrated to possess prognostic predictive value in several diseases. Nonetheless, there is a lack of research on the nutritional risk associated with brain abscess in the older. This study aimed to evaluate the prevalence of nutritional risk among these patients by GNRI and to investigate its potential prognostic value for clinical outcomes.
UNASSIGNED: From August 2019 to April 2023, 100 older patients diagnosed with brain abscess were enrolled in this single-center prospective cohort study, which evaluated the prognostic value of the Geriatric Nutritional Risk Index (GNRI) in elderly brain abscess patients. Data collected included demographic, and clinical characteristics at admission and calculated the GNRI, and the Glasgow Outcome Scale (GOS) score 6 months post-discharge. A GOS score of 5 was considered indicative of a good recovery, whereas scores ranging from 1 to 4 were classified as poor recovery.
UNASSIGNED: The results revealed that 48% of older brain abscess patients were at risk of malnutrition according to the GNRI. These patients had significantly higher post-admission C-reactive protein (CRP) levels (p = 0.017), more comorbidities (p < 0.001), and higher age-adjusted Charlson Comorbidity Index (aCCI) scores (p < 0.001) compared to those without nutritional risk. Spearman correlation analysis showed that GNRI scores were negatively correlated with CRP levels, comorbidities, and aCCI scores, and positively correlated with Glasgow Outcome Scale (GOS) scores (Spearman\'s ρ = 0.624, p < 0.001). Multivariate logistic regression revealed that lower GNRI values were linked to reduced GOS levels (OR = 0.826, 95% CI: 0.775-0.880). ROC analysis determined a GNRI threshold of 97.50 for predicting poor recovery, with 90.57% sensitivity and 87.23% specificity.
UNASSIGNED: The older brain abscess patients exhibited a high malnutrition risk. GNRI showed an important predictive value for recovery in older patients, which could be helpful in clinical intervention and rehabilitation.
UNASSIGNED: From August 2019 to April 2023, 100 older patients diagnosed with brain abscess were enrolled in this single-center prospective cohort study, which evaluated the prognostic value of the Geriatric Nutritional Risk Index (GNRI) in elderly brain abscess patients. Data collected included demographic, and clinical characteristics at admission and calculated the GNRI, and the Glasgow Outcome Scale (GOS) score 6 months post-discharge. A GOS score of 5 was considered indicative of a good recovery, whereas scores ranging from 1 to 4 were classified as poor recovery.
UNASSIGNED: The results revealed that 48% of older brain abscess patients were at risk of malnutrition according to the GNRI. These patients had significantly higher post-admission C-reactive protein (CRP) levels (p = 0.017), more comorbidities (p < 0.001), and higher age-adjusted Charlson Comorbidity Index (aCCI) scores (p < 0.001) compared to those without nutritional risk. Spearman correlation analysis showed that GNRI scores were negatively correlated with CRP levels, comorbidities, and aCCI scores, and positively correlated with Glasgow Outcome Scale (GOS) scores (Spearman\'s ρ = 0.624, p < 0.001). Multivariate logistic regression revealed that lower GNRI values were linked to reduced GOS levels (OR = 0.826, 95% CI: 0.775-0.880). ROC analysis determined a GNRI threshold of 97.50 for predicting poor recovery, with 90.57% sensitivity and 87.23% specificity.
UNASSIGNED: The older brain abscess patients exhibited a high malnutrition risk. GNRI showed an important predictive value for recovery in older patients, which could be helpful in clinical intervention and rehabilitation.
摘要：
老年营养风险指数（GNRI）是老年患者营养筛查的简单而客观的工具，已被证明对几种疾病具有预后预测价值。尽管如此，缺乏对老年人脑脓肿相关营养风险的研究。这项研究旨在通过GNRI评估这些患者中营养风险的患病率，并探讨其对临床结局的潜在预后价值。
■从2019年8月到2023年4月，100名被诊断为脑脓肿的老年患者被纳入这项单中心前瞻性队列研究。评估老年营养风险指数（GNRI）对老年脑脓肿患者的预后价值。收集的数据包括人口统计，和入院时的临床特征，并计算了GNRI，和出院后6个月的格拉斯哥预后量表（GOS）评分。GOS评分为5分被认为表明恢复良好，而1~4分被归类为恢复不良.
■结果显示，根据GNRI，48％的老年脑脓肿患者有营养不良的风险。这些患者入院后C反应蛋白（CRP）水平明显较高（p=0.017），更多的合并症（p<0.001），与没有营养风险的人群相比，年龄校正后的Charlson合并症指数（aCCI）得分更高（p<0.001）。Spearman相关分析显示,GNRI评分与CRP水平呈负相关,合并症,和aCCI分数，与格拉斯哥预后量表（GOS）评分呈正相关（Spearman’sρ=0.624，p<0.001）。多因素logistic回归分析显示，较低的GNRI值与GOS水平降低有关（OR=0.826，95％CI：0.775-0.880）。ROC分析确定的GNRI阈值为97.50，用于预测不良恢复，敏感性为90.57%，特异性为87.23%。
■老年脑脓肿患者表现出很高的营养不良风险。GNRI对老年患者的康复具有重要的预测价值，这可能有助于临床干预和康复。
■从2019年8月到2023年4月，100名被诊断为脑脓肿的老年患者被纳入这项单中心前瞻性队列研究。评估老年营养风险指数（GNRI）对老年脑脓肿患者的预后价值。收集的数据包括人口统计，和入院时的临床特征，并计算了GNRI，和出院后6个月的格拉斯哥预后量表（GOS）评分。GOS评分为5分被认为表明恢复良好，而1~4分被归类为恢复不良.
■结果显示，根据GNRI，48％的老年脑脓肿患者有营养不良的风险。这些患者入院后C反应蛋白（CRP）水平明显较高（p=0.017），更多的合并症（p<0.001），与没有营养风险的人群相比，年龄校正后的Charlson合并症指数（aCCI）得分更高（p<0.001）。Spearman相关分析显示,GNRI评分与CRP水平呈负相关,合并症,和aCCI分数，与格拉斯哥预后量表（GOS）评分呈正相关（Spearman’sρ=0.624，p<0.001）。多因素logistic回归分析显示，较低的GNRI值与GOS水平降低有关（OR=0.826，95％CI：0.775-0.880）。ROC分析确定的GNRI阈值为97.50，用于预测不良恢复，敏感性为90.57%，特异性为87.23%。
■老年脑脓肿患者表现出很高的营养不良风险。GNRI对老年患者的康复具有重要的预测价值，这可能有助于临床干预和康复。
