PDF(Pubmed)
Abstract：
Limited research exists on the mechanisms underlying asthenozoospermia associated with acquired ciliary dyskinesia. Primary ciliary dyskinesia links respiratory pathology with infertility and provides a basis for a potential mechanism. The aetiology of asthenozoospermia is often unclear and may be secondary to direct or indirect effects on sperm motility. Here, we report a case - with a brief clinical review - of recovering sperm motility after diagnosis of complete asthenozoospermia coinciding with resolution of chronic respiratory infections. The patient is a 36-year-old male, with initial semen analysis demonstrating 100% immotile sperm. Following the resolution of chronic respiratory infection, subsequent analysis demonstrated functional improvement with 76 million sperm/mL, 8% progressive motility and 4% strict morphology. Our case reinforces a potentially underappreciated role of environmental risk factors in infertility, with a focus on the patient\'s history of infections and other risk factors for acquired ciliary dyskinesia, which should be kept in mind when treating patients with asthenozoospermia.
摘要：
关于与获得性纤毛运动障碍相关的弱精子症的机制研究有限。原发性纤毛运动障碍将呼吸道病理学与不孕症联系起来，并为潜在的机制提供了基础。弱精子症的病因通常不清楚，可能是直接或间接影响精子运动的继发原因。这里,我们报告了一个病例，并进行了简短的临床回顾，即在诊断为完全弱精子症及慢性呼吸道感染消退后，精子活力得以恢复。病人是一名36岁的男性,最初的精液分析表明精子100％不运动。随着慢性呼吸道感染的解决，随后的分析表明功能改善与7600万精子/毫升，8%的渐进运动和4%的严格形态。我们的案例加强了环境风险因素在不孕症中的潜在作用，重点关注患者的感染史和其他获得性纤毛运动障碍的危险因素，在治疗弱精子症时应该记住这一点。
