PDF(Pubmed)
Abstract：
UNASSIGNED: Human Erythrovirus (parvovirus) B19 infection can produce symptoms similar to those produced by Dengue, Chikungunya, and Zika viruses, making clinical diagnosis difficult. The importance of erythrovirus B19 in human pathology has been increased and reported in numerous studies published globally.
UNASSIGNED: The B19V infection was investigated by real-time PCR in sera samples from patients with signs and symptoms related to classic arboviral symptoms. This study was conducted to provide information on the genetic diversity of Human Erythrovirus B19 (B19V) circulating in the state of Mato Grosso do Sul, Midwest region of Brazil, from 2017 to 2022. A total of 773 sera samples of patients with negative diagnostic results for Dengue, Chikungunya, and Zika, during the study period were analyzed.
UNASSIGNED: Erythrovirus DNA was found in 10.6% (82/773) of patients, among them 10 were pregnant women. Four samples were completely sequenced, and the other five partially, to genotype by phylogenetic reconstruction. All samples belong to worldwide dispersed genotype 1, subgenotype 1a.
UNASSIGNED: The findings of the study demonstrate the importance of including B19V in differential laboratory diagnosis for epidemiological purposes and appropriate patient management. The diagnosis for B19V should be performed, particularly among pregnant women, immunocompromised patients, and individuals with hemolytic diseases, given that the infection is more severe in these cases.
UNASSIGNED: The B19V infection was investigated by real-time PCR in sera samples from patients with signs and symptoms related to classic arboviral symptoms. This study was conducted to provide information on the genetic diversity of Human Erythrovirus B19 (B19V) circulating in the state of Mato Grosso do Sul, Midwest region of Brazil, from 2017 to 2022. A total of 773 sera samples of patients with negative diagnostic results for Dengue, Chikungunya, and Zika, during the study period were analyzed.
UNASSIGNED: Erythrovirus DNA was found in 10.6% (82/773) of patients, among them 10 were pregnant women. Four samples were completely sequenced, and the other five partially, to genotype by phylogenetic reconstruction. All samples belong to worldwide dispersed genotype 1, subgenotype 1a.
UNASSIGNED: The findings of the study demonstrate the importance of including B19V in differential laboratory diagnosis for epidemiological purposes and appropriate patient management. The diagnosis for B19V should be performed, particularly among pregnant women, immunocompromised patients, and individuals with hemolytic diseases, given that the infection is more severe in these cases.
摘要：
■人类红细胞病毒（细小病毒）B19感染可产生与登革热相似的症状，基孔肯雅,和寨卡病毒，使临床诊断变得困难。红细胞病毒B19在人类病理学中的重要性已经增加，并在全球发表的许多研究中报道。
■通过实时PCR在来自具有与经典虫媒病毒症状相关的体征和症状的患者的血清样品中研究B19V感染。进行这项研究是为了提供有关在南马托格罗索州传播的人类红细胞病毒B19（B19V）的遗传多样性的信息，巴西中西部地区，从2017年到2022年。共773份登革热诊断结果阴性的患者血清样本，基孔肯雅,和Zika,在研究期间进行了分析。
■在10.6％（82/773）的患者中发现了红病毒DNA，其中10人是孕妇。四个样本被完全测序，其他五个部分，通过系统发育重建来基因型。所有样品均属于全球分散的基因型1，亚基因型1a。
■这项研究的结果证明了在流行病学和适当的患者管理的鉴别实验室诊断中纳入B19V的重要性。应进行B19V诊断,尤其是孕妇，免疫力低下的患者，和溶血性疾病的个体，鉴于这些病例的感染更为严重。
■通过实时PCR在来自具有与经典虫媒病毒症状相关的体征和症状的患者的血清样品中研究B19V感染。进行这项研究是为了提供有关在南马托格罗索州传播的人类红细胞病毒B19（B19V）的遗传多样性的信息，巴西中西部地区，从2017年到2022年。共773份登革热诊断结果阴性的患者血清样本，基孔肯雅,和Zika,在研究期间进行了分析。
■在10.6％（82/773）的患者中发现了红病毒DNA，其中10人是孕妇。四个样本被完全测序，其他五个部分，通过系统发育重建来基因型。所有样品均属于全球分散的基因型1，亚基因型1a。
■这项研究的结果证明了在流行病学和适当的患者管理的鉴别实验室诊断中纳入B19V的重要性。应进行B19V诊断,尤其是孕妇，免疫力低下的患者，和溶血性疾病的个体，鉴于这些病例的感染更为严重。
