Abstract：
BACKGROUND: Acute pulmonary thromboembolism (PTE) is a life-threatening disease. Considering the availability and accessibility of assessing the serum lipids, this study aims to define the predictive value of lipid profile, as well as the history of lipid disorders, for the mortality of PTE patients.
BACKGROUND: Clinical studies, in which the relation of lipid profile, including triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol, as well as history of imbalance of lipids, with mortality of PTE patients was reported, were included. Non-English articles, reviews, letters, editorials, and non-English papers were excluded. A systematic search was conducted in PubMed, Embase, Scopus, and Web of Science databases. The risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tools and CMA 4 was utilized for the quantitative synthesis. Out of 3,724 records, six studies were included in this systematic review. Lipid profile is suggested as a prognostic marker for survival in patients with PTE so higher initial serum HDL, LDL, and total cholesterol levels were associated with lower mortality rates in PTE patients. In addition, dyslipidemia was found to be associated with mortality of PTE patients. Based on the quantitative synthesis, there was a greater serum level of HDL in the survival group (standardized mean difference: -0.98; 95 % CI: -1.22 to -0.75; p-value<0.01).
UNASSIGNED: Mortality is lower in PTE patients with greater serum lipid levels; therefore, the early prognosis of PTE may be ascertained by measuring serum lipids within the first 24 h of admission.
BACKGROUND: Clinical studies, in which the relation of lipid profile, including triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and total cholesterol, as well as history of imbalance of lipids, with mortality of PTE patients was reported, were included. Non-English articles, reviews, letters, editorials, and non-English papers were excluded. A systematic search was conducted in PubMed, Embase, Scopus, and Web of Science databases. The risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tools and CMA 4 was utilized for the quantitative synthesis. Out of 3,724 records, six studies were included in this systematic review. Lipid profile is suggested as a prognostic marker for survival in patients with PTE so higher initial serum HDL, LDL, and total cholesterol levels were associated with lower mortality rates in PTE patients. In addition, dyslipidemia was found to be associated with mortality of PTE patients. Based on the quantitative synthesis, there was a greater serum level of HDL in the survival group (standardized mean difference: -0.98; 95 % CI: -1.22 to -0.75; p-value<0.01).
UNASSIGNED: Mortality is lower in PTE patients with greater serum lipid levels; therefore, the early prognosis of PTE may be ascertained by measuring serum lipids within the first 24 h of admission.
摘要：
背景：急性肺血栓栓塞症（PTE）是一种危及生命的疾病。考虑到评估血脂的可用性和可及性，这项研究旨在定义血脂谱的预测价值，以及血脂紊乱的病史，PTE患者的死亡率。
背景：临床研究，其中脂质分布的关系，包括甘油三酯（TG），低密度脂蛋白（LDL），高密度脂蛋白（HDL），和总胆固醇，以及血脂失衡的历史，报告了PTE患者的死亡率，包括在内。非英语文章,reviews,信件,社论,非英语论文被排除在外。在PubMed进行了系统的搜索，Embase,Scopus,和WebofScience数据库。使用JoannaBriggs研究所（JBI）关键评估工具评估偏倚风险，并使用CMA4进行定量综合。在3,724条记录中,本系统综述纳入了6项研究.血脂谱被认为是PTE患者生存的预后指标，因此初始血清HDL较高，LDL,和总胆固醇水平与PTE患者死亡率较低相关.此外,发现血脂异常与PTE患者的死亡率相关.在定量合成的基础上，存活组血清HDL水平较高(标准化平均差:-0.98;95%CI:-1.22至-0.75;p值<0.01)。
■血清脂质水平较高的PTE患者死亡率较低；因此，PTE的早期预后可以通过在入院的前24小时内测量血脂来确定。
背景：临床研究，其中脂质分布的关系，包括甘油三酯（TG），低密度脂蛋白（LDL），高密度脂蛋白（HDL），和总胆固醇，以及血脂失衡的历史，报告了PTE患者的死亡率，包括在内。非英语文章,reviews,信件,社论,非英语论文被排除在外。在PubMed进行了系统的搜索，Embase,Scopus,和WebofScience数据库。使用JoannaBriggs研究所（JBI）关键评估工具评估偏倚风险，并使用CMA4进行定量综合。在3,724条记录中,本系统综述纳入了6项研究.血脂谱被认为是PTE患者生存的预后指标，因此初始血清HDL较高，LDL,和总胆固醇水平与PTE患者死亡率较低相关.此外,发现血脂异常与PTE患者的死亡率相关.在定量合成的基础上，存活组血清HDL水平较高(标准化平均差:-0.98;95%CI:-1.22至-0.75;p值<0.01)。
■血清脂质水平较高的PTE患者死亡率较低；因此，PTE的早期预后可以通过在入院的前24小时内测量血脂来确定。
