Abstract：
Skin aging results from complex interactions of intrinsic and extrinsic factors, leading to structural and biochemical changes such as wrinkles and dryness. Ultraviolet (UV) irradiation leads to the degradation of hyaluronic acid (HA) in the skin, and the with fragmented HA contributes to inflammation. This study revealed that the synergistic combination of carnosine and retinol (ROL) increases HA production in normal human epidermal keratinocytes (NHEKs) by upregulating hyaluronan synthase 2 (HAS2) gene transcription. Simultaneously, the combined treatment of carnosine and ROL significantly attenuates UVB-induced prostaglandin E2 (PGE2) synthesis in NHEKs. A significant correlation exists between the increase of HA synthesis and the inhibition of PGE2 production. This study suggested that combined treatment of carnosine and ROL can improve skin aging phenotypes associated with UVB irradiation.
摘要：
皮肤老化是由内在和外在因素的复杂相互作用引起的，导致结构和生化变化，如皱纹和干燥。紫外线（UV）照射导致皮肤中透明质酸（HA）的降解，和破碎的HA有助于炎症。这项研究表明，肌肽和视黄醇（ROL）的协同组合通过上调透明质酸合酶2（HAS2）基因转录来增加正常人表皮角质形成细胞（NHEK）中HA的产生。同时,肌肽和ROL的联合治疗显着减弱了UVB诱导的NHEK中前列腺素E2（PGE2）的合成。HA合成的增加与PGE2产生的抑制之间存在显着相关性。这项研究表明，肌肽和ROL的联合治疗可以改善与UVB照射相关的皮肤老化表型。
