PDF(Pubmed)
Abstract：
BACKGROUND: The underlying mechanisms of post-COVID syndrome (PCS) are still not fully understood. While pre-existing conditions have been described as a risk factor for severe PCS in the general population, data specific to different occupational groups in this context is lacking. This study aimed to investigate the impact of pre-existing conditions on severe post-COVID syndrome among the occupational group of healthcare and social services employees.
METHODS: Baseline data from a longitudinal, observational study were analysed. In February 2021, health workers who had a COVID-19 infection in 2020 were surveyed about sequelae of the infection. Factors influencing severe PCS with at least one persistent symptom categorised as severe were subjected to a multivariate logistic regression analysis.
RESULTS: Of a total of 2,053 participants, 21.5% had severe PCS. Underlying respiratory (OR 1.94; CI 1.44-2.61), cardiovascular (OR 1.35; CI 1.04-1.77) and urogenital (OR 1.79; CI 1.10-2.91) disease were risk factors for severe PCS overall. Respiratory and mental illnesses had a statistically significant impact on persistent fatigue/exhaustion, concentration/memory difficulties and shortness of breath categorised as severe. Urogenital disease was associated with severe fatigue/exhaustion. Other significant risk factors for severe PCS were female sex, smoking, physical exercise and hospitalisation due to COVID-19 infection.
CONCLUSIONS: Workers in healthcare and social services with pre-existing conditions may face a higher risk of developing severe PCS. Additional analyses performed as part of the longitudinal study will show if and how this result changes over time.
METHODS: Baseline data from a longitudinal, observational study were analysed. In February 2021, health workers who had a COVID-19 infection in 2020 were surveyed about sequelae of the infection. Factors influencing severe PCS with at least one persistent symptom categorised as severe were subjected to a multivariate logistic regression analysis.
RESULTS: Of a total of 2,053 participants, 21.5% had severe PCS. Underlying respiratory (OR 1.94; CI 1.44-2.61), cardiovascular (OR 1.35; CI 1.04-1.77) and urogenital (OR 1.79; CI 1.10-2.91) disease were risk factors for severe PCS overall. Respiratory and mental illnesses had a statistically significant impact on persistent fatigue/exhaustion, concentration/memory difficulties and shortness of breath categorised as severe. Urogenital disease was associated with severe fatigue/exhaustion. Other significant risk factors for severe PCS were female sex, smoking, physical exercise and hospitalisation due to COVID-19 infection.
CONCLUSIONS: Workers in healthcare and social services with pre-existing conditions may face a higher risk of developing severe PCS. Additional analyses performed as part of the longitudinal study will show if and how this result changes over time.
摘要：
背景：COVID后综合征（PCS）的潜在机制仍未完全了解。虽然先前存在的疾病已被描述为一般人群中严重PCS的危险因素，在这种情况下，缺乏针对不同职业群体的数据。这项研究旨在调查医疗保健和社会服务雇员的职业人群中先前存在的疾病对严重的COVID后综合征的影响。
方法：来自纵向，对观察性研究进行了分析。2021年2月，对2020年感染COVID-19的卫生工作者进行了关于感染后遗症的调查。对影响至少有一种持续症状被分类为严重的严重PCS的因素进行了多变量逻辑回归分析。
结果：共有2,053名参与者，21.5%有严重的PCS。潜在呼吸（OR1.94；CI1.44-2.61），心血管疾病(OR1.35;CI1.04-1.77)和泌尿生殖系统疾病(OR1.79;CI1.10-2.91)是重度PCS整体的危险因素.呼吸系统和精神疾病对持续性疲劳/疲惫有统计学意义的影响，注意力/记忆困难和呼吸急促归类为严重。泌尿生殖道疾病与严重的疲劳/疲惫有关。严重PCS的其他重要危险因素是女性，吸烟,COVID-19感染导致的体育锻炼和住院。
结论：医疗和社会服务中已有疾病的工作者可能面临更高的患严重PCS的风险。作为纵向研究的一部分进行的其他分析将显示此结果是否以及如何随时间变化。
方法：来自纵向，对观察性研究进行了分析。2021年2月，对2020年感染COVID-19的卫生工作者进行了关于感染后遗症的调查。对影响至少有一种持续症状被分类为严重的严重PCS的因素进行了多变量逻辑回归分析。
结果：共有2,053名参与者，21.5%有严重的PCS。潜在呼吸（OR1.94；CI1.44-2.61），心血管疾病(OR1.35;CI1.04-1.77)和泌尿生殖系统疾病(OR1.79;CI1.10-2.91)是重度PCS整体的危险因素.呼吸系统和精神疾病对持续性疲劳/疲惫有统计学意义的影响，注意力/记忆困难和呼吸急促归类为严重。泌尿生殖道疾病与严重的疲劳/疲惫有关。严重PCS的其他重要危险因素是女性，吸烟,COVID-19感染导致的体育锻炼和住院。
结论：医疗和社会服务中已有疾病的工作者可能面临更高的患严重PCS的风险。作为纵向研究的一部分进行的其他分析将显示此结果是否以及如何随时间变化。
