Abstract：
OBJECTIVE: The extent of health-related quality of life (HRQOL) impairments in older hematological cancer survivors (HCS) has not been sufficiently studied. We therefore examined HRQOL in older HCS compared to a community sample (CS) and investigated sociodemographic, disease- and treatment-specific, geriatric, and psychosocial factors associated with reduced HRQOL.
METHODS: In this cancer-register-based cross-sectional comparative study 200 HCS, aged ≥70 years, and 252 persons of an age- and gender-matched CS completed validated questionnaires including the EORTC QLQ-C30 and EORTC QLQ-ELD14.
RESULTS: Older HCS reported a reduced HRQOL in the dimensions of global QOL, physical, role, and social functioning (small clinical significance) and higher symptom burden of fatigue, nausea and vomiting, appetite loss, and poorer mobility compared to the CS (fatigue and mobility with medium, the others with small clinical significance). Perceived disease burden of comorbidities, functional disabilities, psychological distress, and depression showed statistical significance for reduced HRQOL in older HCS in multiple linear regression analysis (R2 = .602, p < .001).
CONCLUSIONS: The screening and treatment of functional limitations and individual symptoms and the integration of a geriatric assessment into oncological practice can help to identify supportive care needs, to implement individualized, patient-centered cancer survivorship care programs and to improve older HCS\'s HRQOL.
METHODS: In this cancer-register-based cross-sectional comparative study 200 HCS, aged ≥70 years, and 252 persons of an age- and gender-matched CS completed validated questionnaires including the EORTC QLQ-C30 and EORTC QLQ-ELD14.
RESULTS: Older HCS reported a reduced HRQOL in the dimensions of global QOL, physical, role, and social functioning (small clinical significance) and higher symptom burden of fatigue, nausea and vomiting, appetite loss, and poorer mobility compared to the CS (fatigue and mobility with medium, the others with small clinical significance). Perceived disease burden of comorbidities, functional disabilities, psychological distress, and depression showed statistical significance for reduced HRQOL in older HCS in multiple linear regression analysis (R2 = .602, p < .001).
CONCLUSIONS: The screening and treatment of functional limitations and individual symptoms and the integration of a geriatric assessment into oncological practice can help to identify supportive care needs, to implement individualized, patient-centered cancer survivorship care programs and to improve older HCS\'s HRQOL.
摘要：
目的：老年血液肿瘤幸存者（HCS）的健康相关生活质量（HRQOL）受损程度尚未得到充分研究。因此，我们与社区样本(CS)相比，检查了老年HCS的HRQOL，并调查了社会人口统计学，疾病和治疗特异性，老年病学,和心理社会因素与HRQOL降低相关。
方法：在这项基于癌症登记的横断面比较研究中，200例HCS，年龄≥70岁，252名年龄和性别匹配的CS人员完成了经过验证的问卷，包括EORTCQLQ-C30和EORTCQLQ-ELD14。
结果：较老的HCS报告了全球QOL维度中的HRQOL降低，物理，角色,社会功能（临床意义小）和更高的疲劳症状负担，恶心和呕吐，食欲减退,与CS相比，流动性较差(中等强度的疲劳和流动性，其他临床意义较小)。共病的感知疾病负担，功能性残疾,心理困扰,在多元线性回归分析中，抑郁症和抑郁症对老年HCS患者的HRQOL降低有统计学意义（R2=.602，p<.001）。
结论：功能限制和个体症状的筛查和治疗以及将老年评估纳入肿瘤学实践可以帮助确定支持性护理需求，为了实现个性化，以患者为中心的癌症生存护理计划和改善老年HCS的HRQOL。
方法：在这项基于癌症登记的横断面比较研究中，200例HCS，年龄≥70岁，252名年龄和性别匹配的CS人员完成了经过验证的问卷，包括EORTCQLQ-C30和EORTCQLQ-ELD14。
结果：较老的HCS报告了全球QOL维度中的HRQOL降低，物理，角色,社会功能（临床意义小）和更高的疲劳症状负担，恶心和呕吐，食欲减退,与CS相比，流动性较差(中等强度的疲劳和流动性，其他临床意义较小)。共病的感知疾病负担，功能性残疾,心理困扰,在多元线性回归分析中，抑郁症和抑郁症对老年HCS患者的HRQOL降低有统计学意义（R2=.602，p<.001）。
结论：功能限制和个体症状的筛查和治疗以及将老年评估纳入肿瘤学实践可以帮助确定支持性护理需求，为了实现个性化，以患者为中心的癌症生存护理计划和改善老年HCS的HRQOL。
