Abstract：
Osteogenic differentiation is a crucial process in the formation of the skeleton and the remodeling of bones. It relies on a complex system of signaling pathways and transcription factors, including Runt-related transcription factor 2 (RUNX2). Non-coding RNAs (ncRNAs) control the bone-specific transcription factor RUNX2 through post-transcriptional mechanisms to regulate osteogenic differentiation. The most research has focused on microRNAs (miRNAs) and long ncRNAs (lncRNAs) in studying how they regulate RUNX2 for osteogenesis in both normal and pathological situations. This article provides a concise overview of the recent advancements in understanding the critical roles of lncRNA/miRNA/axes in controlling the expression of RUNX2 during bone formation. The possible application of miRNAs and lncRNAs as therapeutic agents for the treatment of disorders involving the bones and bones itself is also covered.
摘要：
成骨分化是骨骼形成和骨骼重塑的关键过程。它依赖于信号通路和转录因子的复杂系统，包括Runt相关转录因子2(RUNX2)。非编码RNA(ncRNA)通过转录后机制控制骨特异性转录因子RUNX2以调节成骨分化。大多数研究集中在microRNAs（miRNAs）和lncRNAs（lncRNAs）上，以研究它们如何在正常和病理情况下调节RUNX2的成骨作用。本文简要概述了lncRNA/miRNA/轴在骨形成过程中控制RUNX2表达的关键作用的最新进展。还涵盖了miRNA和lncRNA作为治疗涉及骨骼和骨骼本身的疾病的治疗剂的可能应用。
