Abstract：
This study investigates gonadal histology in individuals with Turner syndrome assigned female at birth and Y-chromosome material (TS+Y) who underwent prophylactic gonadectomy. Despite case reports suggesting spontaneous menarche and pregnancies in TS+Y, this research reveals the absence of germ cells, indicating low fertility likelihood. Germ cell neoplasia in-situ was present in some patients, emphasizing a non-negligible risk of cancer precursor. As no malignancies were found even in older individuals, the study challenges the immediate need for prophylactic gonadectomy upon TS+Y diagnosis. Limited fertility benefits are suggested, emphasizing the need for further research on optimal timing and criteria for the procedure.
摘要：
这项研究调查了患有特纳综合征的个体的性腺组织学，这些个体在出生时被分配为女性，并且接受了预防性性腺切除术的Y染色体材料（TSY）。尽管有病例报告表明TS+Y有自发性初潮和妊娠，这项研究揭示了生殖细胞的缺失，表明生育率低的可能性。一些患者存在原位生殖细胞瘤形成，强调癌症前体的不可忽视的风险。因为即使在老年人中也没有发现恶性肿瘤，这项研究对TS+Y诊断后立即需要预防性性腺切除术提出了挑战.建议有限的生育福利，强调需要进一步研究程序的最佳时机和标准。
