METHODS: In this cross-sectional study in 2019, paired urine and rectal samples from symptomatic and asymptomatic MSM attending a sexually transmitted infection clinic in the south of Sweden were screened for M. genitalium, presence of MRM, Neisseria gonorrhoeae, Chlamydia trachomatis, HIV and syphilis.
RESULTS: The overall prevalence of M. genitalium was 10.5% (64 of 609), rectal samples 7.6% (46 of 609) and urine samples 3.9% (24 of 609) (p=0.007). Among M. genitalium-positive cases, single rectal and single urethral infection was detected in 62.5% (40 of 64) and 28.1% (18 of 64), respectively (p<0.0001). Infection at both sites was seen in 9.4% (6 of 64). The prevalence of MRM was 67.9% (19 of 28). M. genitalium was significantly associated with HIV (OR 2.60, 95% CI 1.14 to 5.88, p=0.02). Among the MSM, 7.4% (45 of 609) were infected with N. gonorrhoeae, 6.7% (41 of 609) with C. trachomatis, 7.1% (43 of 609) with HIV and 0.7% (4 of 609) with syphilis.
CONCLUSIONS: In this study, among MSM, most infections with M. genitalium were detected as rectal mono infections. The prevalence of M. genitalium among MSM was almost twofold higher in rectal samples (7.6%) compared with urine samples (3.9%). The prevalence of macrolide resistance was high with no difference between urine and rectal samples.
方法:在2019年的这项横断面研究中,对来自瑞典南部性传播感染诊所的有症状和无症状MSM的配对尿液和直肠样本进行了生殖支原体筛查,MRM的存在,淋病奈瑟菌,沙眼衣原体,艾滋病毒和梅毒。
结果:生殖分枝杆菌的总体患病率为10.5%(609个中的64个),直肠样本7.6%(609个样本中的46个)和尿液样本3.9%(609个样本中的24个)(p=0.007)。在生殖支原体阳性病例中,在62.5%(64个中的40个)和28.1%(64个中的18个)中检测到单个直肠和单个尿道感染,分别(p<0.0001)。两个部位的感染均为9.4%(64个中的6个)。MRM的患病率为67.9%(28个中的19个)。生殖分枝杆菌与HIV显著相关(OR2.60,95%CI1.14至5.88,p=0.02)。在MSM中,7.4%(609人中有45人)感染淋病奈瑟菌,6.7%(609人中的41人)患有沙眼衣原体,7.1%(609人中的43人)感染艾滋病毒,0.7%(609人中的4人)感染梅毒。
结论:在这项研究中,在MSM中,大多数生殖器分枝杆菌感染被检测为直肠单一感染。与尿液样本(3.9%)相比,直肠样本(7.6%)中MSM的生殖支原体患病率几乎高出两倍。大环内酯耐药性的患病率很高,尿液和直肠样本之间没有差异。