PDF(Pubmed)
Abstract：
This study was to investigate the role of serum Klotho, fetuin-A, and Matrix Gla Protein (MGP) in Coronary Artery Calcification (CAC) in patients with Maintenance Hemodialysis (MHD) and their predictive value for CAC.
100 patients receiving MHD were selected. Serum Klotho, fetuin-A, and MGP levels were detected by ELISA. CAC scores were assessed by coronary CT scan. Multifactor analysis was used to evaluate the risk factors affecting CAC. The ability of serum Klotho, fetuin-A, and MGP levels to diagnose CAC was evaluated by receiver operating characteristic curves.
Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC. Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.
There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.
100 patients receiving MHD were selected. Serum Klotho, fetuin-A, and MGP levels were detected by ELISA. CAC scores were assessed by coronary CT scan. Multifactor analysis was used to evaluate the risk factors affecting CAC. The ability of serum Klotho, fetuin-A, and MGP levels to diagnose CAC was evaluated by receiver operating characteristic curves.
Serum Klotho, fetuin-A, and MGP were independent risk factors for CAC. Serum Klotho, fetuin-A, and MGP were valuable in the diagnosis of CAC in MHD patients.
There is a close relationship between Klotho, fetuin-A, and MGP levels in MHD patients and CAC.
摘要：
目的：本研究旨在探讨血清Klotho的作用，fetuin-A,维持性血液透析（MHD）患者冠状动脉钙化（CAC）中的基质Gla蛋白（MGP）及其对CAC的预测价值。
方法：选择100例接受MHD的患者。血清Klotho,fetuin-A,用ELISA法检测MGP水平。通过冠状动脉CT扫描评估CAC评分。采用多因素分析评价影响CAC的危险因素。血清Klotho的能力，fetuin-A,通过受试者工作特征曲线评估诊断CAC的MGP水平。
结果：血清Klotho，fetuin-A,MGP是CAC的独立危险因素。血清Klotho,fetuin-A,MGP对MHD患者CAC的诊断有价值。
结论：Klotho，fetuin-A,MHD患者和CAC的MGP水平。
方法：选择100例接受MHD的患者。血清Klotho,fetuin-A,用ELISA法检测MGP水平。通过冠状动脉CT扫描评估CAC评分。采用多因素分析评价影响CAC的危险因素。血清Klotho的能力，fetuin-A,通过受试者工作特征曲线评估诊断CAC的MGP水平。
结果：血清Klotho，fetuin-A,MGP是CAC的独立危险因素。血清Klotho,fetuin-A,MGP对MHD患者CAC的诊断有价值。
结论：Klotho，fetuin-A,MHD患者和CAC的MGP水平。
