Abstract：
Oxytocin can regulate immunological activity directly or indirectly; however, immunological functions and mechanisms of oxytocin actions under chronic stress like cesarean delivery (CD) are poorly understood. Our study found that abnormal oxytocin production and secretion in CD rats caused atrophy of thymic tissues. Neurotoxin kainic acid microinjected into the dorsolateral supraoptic nucleus in male rats selectively reduced hypothalamic oxytocin levels, increased corticotrophin-releasing hormone and plasma interleukin-1β while reducing plasma oxytocin, thyroxine and testosterone levels and causing atrophy of immune tissues. Thus, plasma oxytocin is essential for immunological homeostasis, which involves oxytocin facilitation of thyroid hormone and sex steroid secretion.
摘要：
催产素可以直接或间接调节免疫活性;然而,在剖宫产（CD）等慢性应激下的免疫功能和催产素作用机制尚不清楚。我们的研究发现，CD大鼠的催产素产生和分泌异常会导致胸腺组织萎缩。将神经毒素海藻酸显微注射到雄性大鼠的视上背外侧核选择性地降低下丘脑催产素水平，促肾上腺皮质激素释放激素和血浆白细胞介素-1β增加，同时减少血浆催产素，甲状腺素和睾酮水平和引起免疫组织萎缩。因此，血浆催产素对于免疫稳态至关重要，其中涉及催产素促进甲状腺激素和性类固醇分泌。
