Abstract：
P53 tumor suppressor is a major regulator of various cellular processes and functions. It has been reported that mutation or inactivation of p53 plays a crucial role in tumorigenesis in different types of cancers. Circular RNAs (circRNAs) are single-stranded non-coding RNAs that have significant post-transcriptional effects on the regulation of gene expression in various ways. These molecules can alter the expression and function of multiple genes and proteins. In the present study, we aimed to review circRNAs that regulate the expression, function, and stability of p53 and the possible interactions between these molecules and p53. Considering the importance of p53 in cancer and the network between p53 and circRNAs, future clinical trials targeting these circRNAs as therapeutic agents deserve worthy of attention.
摘要：
P53肿瘤抑制因子是各种细胞过程和功能的主要调节因子。据报道，p53的突变或失活在不同类型癌症的肿瘤发生中起着至关重要的作用。环状RNA(circularRNAs,circRNAs)是单链非编码RNA,其以各种方式对基因表达的调节具有显著的转录后效应。这些分子可以改变多种基因和蛋白质的表达和功能。在本研究中,我们的目的是回顾调节表达的circRNAs，函数,和p53的稳定性以及这些分子与p53之间可能的相互作用。考虑到p53在癌症中的重要性以及p53和circRNAs之间的网络，针对这些circRNAs作为治疗药物的未来临床试验值得关注.
