RAN 的抑制减弱甲型流感病毒复制和核蛋白核输出。
关键词: Influenza A virus RAN bepotastine nuclear export viral ribonucleoprotein
Mesh : Virus Replication / drug effects Humans ran GTP-Binding Protein / metabolism genetics Antiviral Agents / pharmacology Animals Influenza A virus / drug effects physiology Active Transport, Cell Nucleus Exportin 1 Protein Karyopherins / metabolism antagonists & inhibitors Dogs Receptors, Cytoplasmic and Nuclear / metabolism genetics Madin Darby Canine Kidney Cells Viral Nonstructural Proteins / metabolism genetics Mice Piperidines / pharmacology Influenza, Human / virology A549 Cells Nucleoproteins / metabolism genetics HEK293 Cells Cell Line Cell Nucleus / metabolism Ribonucleoproteins / metabolism genetics
来 源:
DOI:10.1080/22221751.2024.2387910
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