PDF(Pubmed)
Abstract：
Migraines are a type of headache that occur with other neurological symptoms, but the pathophysiology remains unclear. In this issue of the JCI, Nelson-Maney and authors used constitutive and inducible knockouts of the CGRP receptor components, elegantly demonstrating an essential function of CGRP in modulating meningeal lymphatic vessels (MLVs) in migraine. CGRP was shown to induce rearrangement of membrane-bound gap junction proteins in MLVs, resulting in a reduced CSF flux into cervical lymph nodes. The authors also provided evidence of a primary role for CGRP in modulating neuro-immune function. Finally, by showing that blocking CGRP signaling in MLVs attenuated pain behavior associated with acute migraine in rodents, the authors provided a target for pharmacological blockade of CGRP in relation to primary headache disorders.
摘要：
偏头痛是一种伴随其他神经系统症状的头痛，但病理生理学仍不清楚。在本期JCI中，Nelson-Maney和作者使用了CGRP受体成分的组成型和诱导型敲除，优雅地证明了CGRP在调节偏头痛的脑膜淋巴管（MLV）中的基本功能。CGRP被证明可以诱导MLV中膜结合间隙连接蛋白的重排，导致流入颈部淋巴结的脑脊液减少。作者还提供了CGRP在调节神经免疫功能中的主要作用的证据。最后,通过显示阻断MLV中的CGRP信号传导减轻了啮齿动物中与急性偏头痛相关的疼痛行为，作者提供了与原发性头痛疾病相关的CGRP药物阻断的靶点.
