PDF(Pubmed)
Abstract：
This case report describes a 26-year-old female with a history of childhood depression who experienced severe gastrointestinal symptoms and significant weight loss following the discontinuation of venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI). After tapering off the medication, days after cessation, she developed early satiety, nausea, bloating, and vomiting, leading to severe malnutrition with a body mass index (BMI) of 14. Despite the onset of symptoms being within the typical duration for discontinuation syndrome, extensive medical evaluations revealed no physical cause for her symptoms. Psychological assessment showed no current depression or anxiety, and she denied any eating disorder behaviors, suggesting a prolonged discontinuation syndrome. Her symptoms improved with the initiation of mirtazapine. This case underscores the importance of careful management when discontinuing venlafaxine, highlighting the potential for prolonged and severe discontinuation symptoms.
摘要：
该病例报告描述了一名26岁的女性，有儿童抑郁症史，在停用文拉法辛后出现严重的胃肠道症状和明显的体重减轻。5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)。在逐渐减少药物后，停止后几天，她产生了早期饱腹感，恶心,腹胀,呕吐,导致体重指数（BMI）为14的严重营养不良。尽管症状的发作在停药综合征的典型持续时间内，广泛的医学评估显示她的症状没有身体原因。心理评估显示目前没有抑郁或焦虑，她否认有任何饮食失调行为，提示长期停药综合征.开始服用米氮平后，她的症状有所改善。这个案例强调了停用文拉法辛时谨慎管理的重要性,强调长期和严重的停药症状的可能性。
