PDF(Pubmed)
Abstract：
BACKGROUND: Surgical intervention involving the pancreas can lead to impaired glucose tolerance and other types of endocrine dysfunction. The scope of pancreatectomy and whether it includes the ventral pancreas are the key factors in the development of postoperative diabetes. The ventral and dorsal pancreases are almost separated in Suncus murinus (S. murinus).
OBJECTIVE: To investigate the effects of different extents of pancreatic resection on endocrine function in S. murinus.
METHODS: Eight-week-old male S. murinus shrews were randomly divided into three experimental groups according to different pancreatic resection ranges as follows: ventral pancreatectomy (VPx) group; partial pancreatectomy (PPx) group; subtotal pancreatectomy (SPx) group; and a sham-operated group. Postprandial serum insulin, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and somatostatin (SST) levels, as well as food intake, weight, blood glucose, and glucose tolerance were regularly measured for each animal.
RESULTS: S. murinus treated with PPx and SPx suffered from varying degrees of impaired glucose tolerance, but only a small proportion of the SPx group developed diabetes. Only S. murinus in the SPx group showed a significant decrease in food intake accompanied by severe weight loss, as well as a significant increase in postprandial serum GLP-1 levels. Postprandial serum PP levels decreased in both the VPx and PPx groups, but not in the SPx group. Postprandial serum SST levels decreased in both VPx and PPx groups, but the decrease was marginal.
CONCLUSIONS: Severe weight loss after pancreatectomy may be related to loss of appetite caused by compensatory elevation of GLP-1. PP and GLP-1 may play a role in resisting blood glucose imbalance.
OBJECTIVE: To investigate the effects of different extents of pancreatic resection on endocrine function in S. murinus.
METHODS: Eight-week-old male S. murinus shrews were randomly divided into three experimental groups according to different pancreatic resection ranges as follows: ventral pancreatectomy (VPx) group; partial pancreatectomy (PPx) group; subtotal pancreatectomy (SPx) group; and a sham-operated group. Postprandial serum insulin, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and somatostatin (SST) levels, as well as food intake, weight, blood glucose, and glucose tolerance were regularly measured for each animal.
RESULTS: S. murinus treated with PPx and SPx suffered from varying degrees of impaired glucose tolerance, but only a small proportion of the SPx group developed diabetes. Only S. murinus in the SPx group showed a significant decrease in food intake accompanied by severe weight loss, as well as a significant increase in postprandial serum GLP-1 levels. Postprandial serum PP levels decreased in both the VPx and PPx groups, but not in the SPx group. Postprandial serum SST levels decreased in both VPx and PPx groups, but the decrease was marginal.
CONCLUSIONS: Severe weight loss after pancreatectomy may be related to loss of appetite caused by compensatory elevation of GLP-1. PP and GLP-1 may play a role in resisting blood glucose imbalance.
摘要：
背景：涉及胰腺的手术干预可导致葡萄糖耐量受损和其他类型的内分泌功能障碍。胰腺切除范围及是否包括腹侧胰腺是术后糖尿病发生发展的关键因素。在Suncusmurinus中，腹侧和背侧胰腺几乎分开（S.murinus).
目的：探讨不同程度的胰腺切除对鼠疫杆菌内分泌功能的影响。
方法：将8周龄雄性鼠尾草按不同的胰腺切除范围随机分为3个实验组：腹侧胰腺切除术(VPx)组、部分胰腺切除术(PPx)组、次全胰腺切除术(SPx)组和假手术组。餐后血清胰岛素，胰高血糖素样肽-1(GLP-1),胰多肽（PP），和生长抑素（SST）水平，以及食物摄入，体重,血糖，定期测量每只动物的葡萄糖耐量。
结果：S.用PPx和SPx治疗的murinus患有不同程度的葡萄糖耐量受损，但只有一小部分SPx组患了糖尿病.SPx组仅有murinus表现出食物摄入显著减少，伴随着严重的体重减轻，以及餐后血清GLP-1水平显着增加。VPx和PPx组的餐后血清PP水平均下降，但不在SPx组中。VPx和PPx组的餐后血清SST水平均下降，但减少是微不足道的。
结论：胰腺切除术后体重严重下降可能与GLP-1代偿性升高引起的食欲不振有关。PP和GLP-1可能在抵抗血糖失衡方面发挥作用。
目的：探讨不同程度的胰腺切除对鼠疫杆菌内分泌功能的影响。
方法：将8周龄雄性鼠尾草按不同的胰腺切除范围随机分为3个实验组：腹侧胰腺切除术(VPx)组、部分胰腺切除术(PPx)组、次全胰腺切除术(SPx)组和假手术组。餐后血清胰岛素，胰高血糖素样肽-1(GLP-1),胰多肽（PP），和生长抑素（SST）水平，以及食物摄入，体重,血糖，定期测量每只动物的葡萄糖耐量。
结果：S.用PPx和SPx治疗的murinus患有不同程度的葡萄糖耐量受损，但只有一小部分SPx组患了糖尿病.SPx组仅有murinus表现出食物摄入显著减少，伴随着严重的体重减轻，以及餐后血清GLP-1水平显着增加。VPx和PPx组的餐后血清PP水平均下降，但不在SPx组中。VPx和PPx组的餐后血清SST水平均下降，但减少是微不足道的。
结论：胰腺切除术后体重严重下降可能与GLP-1代偿性升高引起的食欲不振有关。PP和GLP-1可能在抵抗血糖失衡方面发挥作用。
