PDF(Pubmed)
Abstract：
Hyperthermia is a promising anticancer treatment modality. Heat stress stimulates proteolytic machineries to regulate cellular homeostasis. Calpain, an intracellular calcium (Ca2+)-dependent cysteine protease, is a modulator that governs various cellular functions. Hyperthermia induces an increase in cytosolic Ca2+ levels and triggers calpain activation. Contrastingly, pre-exposure of cells to mild hyperthermia induces thermotolerance due to the presence of cellular homeostatic processes such as heat shock response and autophagy. Recent studies suggest that calpain is a potential key molecule that links autophagy and apoptosis. In this review, we briefly introduce the regulation of intracellular Ca2+ homeostasis, basic features of calpains with their implications in cancer, immune responses, and the roles and cross-talk of calpains in cellular protection and cell death in hyperthermia.
摘要：
热疗是一种有前途的抗癌治疗方式。热应激刺激蛋白水解机制以调节细胞稳态。钙蛋白酶,细胞内钙（Ca2+）依赖性半胱氨酸蛋白酶，是控制各种细胞功能的调制器。高热诱导胞质Ca2+水平增加并触发钙蛋白酶激活。相反，由于存在细胞稳态过程，如热休克反应和自噬，细胞预暴露于轻度高温会诱导耐热性。最近的研究表明，钙蛋白酶是连接自噬和凋亡的潜在关键分子。在这次审查中,我们简要介绍了细胞内Ca2+稳态的调节，钙蛋白酶的基本特征及其对癌症的影响，免疫反应，以及钙蛋白酶在高热细胞保护和细胞死亡中的作用和串扰。
