PDF(Pubmed)
Abstract：
UNASSIGNED: To compare the macular area parameters and aqueous humor factors between myopia and emmetropia.
UNASSIGNED: Convenience sampling was used to select patients who visited the Changzhi Aier Eye Hospital\'s department of ophthalmology from December 2018 to December 2022 as the study participants. They were divided into three groups according to whether they were diagnosed as mild myopia myopic, highly myopic or not as follows: the mild myopia group (60 cases, 108 eyes), the high myopia group (46 cases, 78 eyes) and the healthy emmetropia group (40 cases, 65 eyes). The differences in the macular integrity (MI) assessment, optical coherence tomography and optical coherence tomography angiography parameters and aqueous humor factors were compared between the three groups.
UNASSIGNED: AL in high myopia group was the highest, and that in emmetropia group was the lowest. The BCVA of mild myopia group was the highest. The RS in the high myopia group were significantly lowest in the three groups (26.42 ± 1.04 vs. 28.34 ± 0.76 vs. 31.92 ± 0.77) (F = 5.374, p = 0.013). The 63% BCEA, 95% BCEA and MI in the high myopia group were significantly highest (p < 0.05). The mean RPE thickness, mean CT and mean RT in the high myopia group were lowest (p < 0.05). The blood flow density were lowest in the superficial fovea, paracentral fovea and different subdivisions of the paracentral fovea in the high myopia group (p < 0.05). The VEGF concentration in the aqueous humor of the high myopia group was lowest (25.62 ± 17.43 vs. 32.45 ± 24.67 vs. 64.37 ± 21.14) (F = 9.237, p < 0.001). The MMP-2 concentration was highest (483 ± 201.48 vs. 410 ± 142.37 vs. 386 ± 154.34) (F = 5.542, p = 0.018). The VEGF concentration in the aqueous humor factor was negatively correlated with the AL in the myopia group (r = -0.438, p = 0.002), the MMP-2 concentration was positively correlated with the AL (r = 0.484, p = 0.010).
UNASSIGNED: Patients with high myopia showed decreased retinal light sensitivity, fixation stability, superficial blood flow density and retinal thickness compared with people with emmetropia. A decreased VEGF concentration and increased MMP-2 concentration in the aqueous humor factor have potential associations with the development of high myopia.
UNASSIGNED: Convenience sampling was used to select patients who visited the Changzhi Aier Eye Hospital\'s department of ophthalmology from December 2018 to December 2022 as the study participants. They were divided into three groups according to whether they were diagnosed as mild myopia myopic, highly myopic or not as follows: the mild myopia group (60 cases, 108 eyes), the high myopia group (46 cases, 78 eyes) and the healthy emmetropia group (40 cases, 65 eyes). The differences in the macular integrity (MI) assessment, optical coherence tomography and optical coherence tomography angiography parameters and aqueous humor factors were compared between the three groups.
UNASSIGNED: AL in high myopia group was the highest, and that in emmetropia group was the lowest. The BCVA of mild myopia group was the highest. The RS in the high myopia group were significantly lowest in the three groups (26.42 ± 1.04 vs. 28.34 ± 0.76 vs. 31.92 ± 0.77) (F = 5.374, p = 0.013). The 63% BCEA, 95% BCEA and MI in the high myopia group were significantly highest (p < 0.05). The mean RPE thickness, mean CT and mean RT in the high myopia group were lowest (p < 0.05). The blood flow density were lowest in the superficial fovea, paracentral fovea and different subdivisions of the paracentral fovea in the high myopia group (p < 0.05). The VEGF concentration in the aqueous humor of the high myopia group was lowest (25.62 ± 17.43 vs. 32.45 ± 24.67 vs. 64.37 ± 21.14) (F = 9.237, p < 0.001). The MMP-2 concentration was highest (483 ± 201.48 vs. 410 ± 142.37 vs. 386 ± 154.34) (F = 5.542, p = 0.018). The VEGF concentration in the aqueous humor factor was negatively correlated with the AL in the myopia group (r = -0.438, p = 0.002), the MMP-2 concentration was positively correlated with the AL (r = 0.484, p = 0.010).
UNASSIGNED: Patients with high myopia showed decreased retinal light sensitivity, fixation stability, superficial blood flow density and retinal thickness compared with people with emmetropia. A decreased VEGF concentration and increased MMP-2 concentration in the aqueous humor factor have potential associations with the development of high myopia.
摘要：
■比较近视和正视眼之间的黄斑面积参数和房水因子。
■采用便利抽样方法选择2018年12月至2022年12月在长治爱尔眼科医院就诊的患者作为研究参与者。根据他们是否被诊断为轻度近视，将他们分为三组，高度近视与否如下：轻度近视组（60例，108只眼睛），高度近视组(46例,78只眼）和健康正视组（40例，65只眼睛）。黄斑完整性（MI）评估的差异，比较3组光学相干断层扫描和光学相干断层扫描血管造影参数和房水因子。
■高度近视组AL最高，在正视组中是最低的。轻度近视组BCVA最高。高度近视组的RS在三组中明显最低（26.42±1.04vs.28.34±0.76vs.31.92±0.77)(F=5.374,p=0.013)。63%的BCEA，高度近视组95%BCEA和MI显著最高(p<0.05)。平均RPE厚度，高度近视组的平均CT和平均RT最低(p<0.05)。浅凹的血流密度最低,高度近视组中央凹和中央凹的不同细分（p<0.05）。高度近视组房水VEGF浓度最低(25.62±17.43vs.32.45±24.67vs.64.37±21.14)(F=9.237,p<0.001)。MMP-2浓度最高（483±201.48vs.410±142.37vs.386±154.34)(F=5.542,p=0.018)。近视组房水因子中VEGF浓度与AL呈负相关(r=-0.438,p=0.002),MMP-2浓度与AL呈正相关(r=0.484,p=0.010)。
■高度近视患者的视网膜光敏感度下降，固定稳定性，浅表血流密度和视网膜厚度与正视眼患者相比。房水因子中VEGF浓度的降低和MMP-2浓度的增加与高度近视的发展具有潜在的关联。
■采用便利抽样方法选择2018年12月至2022年12月在长治爱尔眼科医院就诊的患者作为研究参与者。根据他们是否被诊断为轻度近视，将他们分为三组，高度近视与否如下：轻度近视组（60例，108只眼睛），高度近视组(46例,78只眼）和健康正视组（40例，65只眼睛）。黄斑完整性（MI）评估的差异，比较3组光学相干断层扫描和光学相干断层扫描血管造影参数和房水因子。
■高度近视组AL最高，在正视组中是最低的。轻度近视组BCVA最高。高度近视组的RS在三组中明显最低（26.42±1.04vs.28.34±0.76vs.31.92±0.77)(F=5.374,p=0.013)。63%的BCEA，高度近视组95%BCEA和MI显著最高(p<0.05)。平均RPE厚度，高度近视组的平均CT和平均RT最低(p<0.05)。浅凹的血流密度最低,高度近视组中央凹和中央凹的不同细分（p<0.05）。高度近视组房水VEGF浓度最低(25.62±17.43vs.32.45±24.67vs.64.37±21.14)(F=9.237,p<0.001)。MMP-2浓度最高（483±201.48vs.410±142.37vs.386±154.34)(F=5.542,p=0.018)。近视组房水因子中VEGF浓度与AL呈负相关(r=-0.438,p=0.002),MMP-2浓度与AL呈正相关(r=0.484,p=0.010)。
■高度近视患者的视网膜光敏感度下降，固定稳定性，浅表血流密度和视网膜厚度与正视眼患者相比。房水因子中VEGF浓度的降低和MMP-2浓度的增加与高度近视的发展具有潜在的关联。
