PDF(Pubmed)
Abstract：
Rosai-Dorfman disease (RDD) is a rare disorder characterized by excessive growth of histiocytes. We present a case of a 14-year-old female with cutaneous RDD who had a subcutaneous lump on her left arm for three years. The lump became tender and progressively larger over the past year. She had no systemic symptoms, and her physical examination revealed a mobile, tender lump. Laboratory tests were normal. Surgical excision of the lump was performed, and histopathological examination confirmed RDD with the presence of epithelioid histiocytes with eosinophilic and clear cytoplasm, along with emperipolesis and positive staining for CD68, CD163, S100, and OCT2. The patient was referred for follow-up and required no further treatment. RDD can present with subcutaneous masses without systemic symptoms, and it is important to consider RDD in the differential diagnosis of such cases. Surgical excision is the main treatment, and long-term monitoring is necessary due to the potential for disease recurrence. Awareness of cutaneous RDD presentations is crucial for accurate diagnosis and management.
摘要：
Rosai-Dorfman病（RDD）是一种罕见的疾病，其特征是组织细胞过度生长。我们介绍了一例14岁的皮肤RDD女性，其左臂有皮下肿块三年。在过去的一年中，肿块变软并逐渐变大。她没有全身症状,她的体检显示有一部手机，招标肿块。实验室检查正常。对肿块进行了手术切除，组织病理学检查证实RDD存在嗜酸性细胞和透明细胞质的上皮样组织细胞，伴随着周体注射和CD68，CD163，S100和OCT2的阳性染色。患者被转诊进行随访，不需要进一步治疗。RDD可表现为皮下肿块而无全身症状,在此类病例的鉴别诊断中考虑RDD非常重要。手术切除是主要的治疗方法，由于疾病复发的可能性，长期监测是必要的。对皮肤RDD表现的认识对于准确诊断和管理至关重要。
