PDF(Pubmed)
Abstract：
BACKGROUND: Both Graves\' disease (GD) and Hashimoto\'s thyroiditis (HT) are classified as autoimmune thyroid diseases (AITDs). It has been hypothesized that changes in the thyroid-stimulating hormone receptor (TSHR) gene may contribute to the development of these conditions. This study aimed to analyze the correlation between the TSHR rs179247 gene polymorphism and susceptibility to AITD.
METHODS: We conducted a thorough search of the Google Scholar, Scopus, Medline, and Cochrane Library databases up until March 2, 2024, utilizing a combination of relevant keywords. This review examines data on the association between TSHR rs179247 and susceptibility to AITD. Random-effect models were employed to assess the odds ratio (OR), and the findings are presented along with their respective 95% confidence intervals (CIs).
RESULTS: The meta-analysis included 12 studies. All genetic models of the TSHR rs179247 gene polymorphism were associated with an increased risk of developing GD. Specifically, the associations were observed in the dominant model (OR, 1.65; P<0.00001), recessive model (OR, 1.65; P<0.00001), as well as for the AA genotype (OR, 2.09; P<0.00001), AG genotype (OR, 1.39; P<0.00001), and A allele (OR, 1.44; P<0.00001). Further regression analysis revealed that these associations were consistent regardless of the country of origin, sample size, age, and sex distribution. However, no association was found between TSHR rs179247 and the risk of HT across all genetic models.
CONCLUSIONS: This study suggests that the TSHR rs179247 gene polymorphism is associated with an increased risk of GD, but not with HT, and may therefore serve as a potential biomarker.
METHODS: We conducted a thorough search of the Google Scholar, Scopus, Medline, and Cochrane Library databases up until March 2, 2024, utilizing a combination of relevant keywords. This review examines data on the association between TSHR rs179247 and susceptibility to AITD. Random-effect models were employed to assess the odds ratio (OR), and the findings are presented along with their respective 95% confidence intervals (CIs).
RESULTS: The meta-analysis included 12 studies. All genetic models of the TSHR rs179247 gene polymorphism were associated with an increased risk of developing GD. Specifically, the associations were observed in the dominant model (OR, 1.65; P<0.00001), recessive model (OR, 1.65; P<0.00001), as well as for the AA genotype (OR, 2.09; P<0.00001), AG genotype (OR, 1.39; P<0.00001), and A allele (OR, 1.44; P<0.00001). Further regression analysis revealed that these associations were consistent regardless of the country of origin, sample size, age, and sex distribution. However, no association was found between TSHR rs179247 and the risk of HT across all genetic models.
CONCLUSIONS: This study suggests that the TSHR rs179247 gene polymorphism is associated with an increased risk of GD, but not with HT, and may therefore serve as a potential biomarker.
摘要：
■Graves病（GD）和桥本甲状腺炎（HT）均被归类为自身免疫性甲状腺疾病（AITDs）。据推测，促甲状腺激素受体（TSHR）基因的变化可能有助于这些疾病的发展。本研究旨在分析TSHRrs179247基因多态性与AITD易感性的相关性。
■我们对谷歌学者进行了彻底的搜索，Scopus,Medline,和Cochrane图书馆数据库，直到2024年3月2日，利用相关关键字的组合。这篇综述研究了TSHRrs179247与AITD易感性之间的关联数据。随机效应模型用于评估比值比(OR)，并给出了这些发现以及它们各自的95%置信区间(CI)。
■荟萃分析包括12项研究。TSHRrs179247基因多态性的所有遗传模型都与发生GD的风险增加有关。具体来说,在显性模型(OR，1.65;P<0.00001),隐性模型(或，1.65;P<0.00001),以及AA基因型(OR，2.09;P<0.00001),AG基因型(OR，1.39;P<0.00001),和A等位基因(OR，1.44;P<0.00001)。进一步的回归分析显示，无论原籍国如何，这些关联都是一致的，样本量,年龄,和性别分布。然而,在所有遗传模型中,均未发现TSHRrs179247与HT风险之间存在关联.
■这项研究表明，TSHRrs179247基因多态性与GD的风险增加有关，但不是HT，因此可以作为潜在的生物标志物。
■我们对谷歌学者进行了彻底的搜索，Scopus,Medline,和Cochrane图书馆数据库，直到2024年3月2日，利用相关关键字的组合。这篇综述研究了TSHRrs179247与AITD易感性之间的关联数据。随机效应模型用于评估比值比(OR)，并给出了这些发现以及它们各自的95%置信区间(CI)。
■荟萃分析包括12项研究。TSHRrs179247基因多态性的所有遗传模型都与发生GD的风险增加有关。具体来说,在显性模型(OR，1.65;P<0.00001),隐性模型(或，1.65;P<0.00001),以及AA基因型(OR，2.09;P<0.00001),AG基因型(OR，1.39;P<0.00001),和A等位基因(OR，1.44;P<0.00001)。进一步的回归分析显示，无论原籍国如何，这些关联都是一致的，样本量,年龄,和性别分布。然而,在所有遗传模型中,均未发现TSHRrs179247与HT风险之间存在关联.
■这项研究表明，TSHRrs179247基因多态性与GD的风险增加有关，但不是HT，因此可以作为潜在的生物标志物。
