Abstract：
This opinion piece describes major limitations of using α-synuclein in speculative neuronally enriched for diagnosing or predicting Parkinson\'s disease risk from prodromal conditions such as REM behaviour disorder. It concludes that such an approach is unreliable and recommends that future researchers divert away to more widely accepted approaches such as seed amplification assays.
摘要：
这篇观点文章描述了在推测性神经富集中使用α-突触核蛋白来诊断或预测前驱疾病如REM行为障碍的帕金森病风险的主要局限性。结论是这种方法是不可靠的，并建议未来的研究人员转向更广泛接受的方法，例如种子扩增测定。
