PDF(Pubmed)
Abstract：
OBJECTIVE: Uric acid has been associated with several metabolic conditions, including bone diseases. Our objective here was to consider the relationship between serum uric acid levels and various bone parameters (bone mineral density, ultrasonographic parameters, vitamin D, PTH and serum calcium), as well as the prevalence and risk of fragility fracture.
METHODS: An observational and cross-sectional study carried out on 679 postmenopausal women, classified into 3 groups according to their serum uric acid levels, in whom bone densitometry, calcaneus ultrasounds, PTH, vitamin D and serum calcium analysis were done. Bone fractures were collected through the clinical history and lateral spinal X-ray.
RESULTS: Higher uric acid levels were found in women with older age, high BMI, diabetes, and high blood pressure. Higher levels of PTH and serum calcium were also observed, but did not effect on vitamin D. Serum uric acid was positively related to densitometric and ultrasonic parameters and negatively associated with vertebral fractures.
CONCLUSIONS: In the population of postmenopausal women studied, sUA levels were correlated with BMD, BUA, and QUI-Stiffness, and this correlation was independent of age and BMI. In addition, sUA was associated with a decrease in vertebral fractures. These results imply a beneficial influence of sUA on bone metabolism, with both a quantitative and qualitative positive effect, reflected in the lower prevalence of vertebral fractures.
METHODS: An observational and cross-sectional study carried out on 679 postmenopausal women, classified into 3 groups according to their serum uric acid levels, in whom bone densitometry, calcaneus ultrasounds, PTH, vitamin D and serum calcium analysis were done. Bone fractures were collected through the clinical history and lateral spinal X-ray.
RESULTS: Higher uric acid levels were found in women with older age, high BMI, diabetes, and high blood pressure. Higher levels of PTH and serum calcium were also observed, but did not effect on vitamin D. Serum uric acid was positively related to densitometric and ultrasonic parameters and negatively associated with vertebral fractures.
CONCLUSIONS: In the population of postmenopausal women studied, sUA levels were correlated with BMD, BUA, and QUI-Stiffness, and this correlation was independent of age and BMI. In addition, sUA was associated with a decrease in vertebral fractures. These results imply a beneficial influence of sUA on bone metabolism, with both a quantitative and qualitative positive effect, reflected in the lower prevalence of vertebral fractures.
摘要：
目的：尿酸与几种代谢状况有关，包括骨骼疾病。我们的目标是考虑血清尿酸水平与各种骨参数（骨矿物质密度，超声参数,维生素D,PTH和血清钙），以及脆性骨折的患病率和风险。
方法：一项对679名绝经后妇女进行的观察性和横断面研究，根据血清尿酸水平分为3组，骨密度仪，跟骨超声,PTH,维生素D和血清钙分析。通过临床病史和脊柱侧位X线收集骨折。
结果：老年女性的尿酸水平较高，高BMI,糖尿病,还有高血压.还观察到更高水平的PTH和血清钙，但对维生素D无影响。血清尿酸与光密度和超声参数呈正相关，与椎体骨折呈负相关。
结论：在研究的绝经后妇女人群中，sUA水平与BMD相关，BUA,和QUI-刚度，这种相关性与年龄和BMI无关。此外,sUA与椎体骨折减少有关。这些结果暗示了sUA对骨代谢的有益影响，具有定量和定性的积极作用，反映在椎骨骨折的患病率较低。
方法：一项对679名绝经后妇女进行的观察性和横断面研究，根据血清尿酸水平分为3组，骨密度仪，跟骨超声,PTH,维生素D和血清钙分析。通过临床病史和脊柱侧位X线收集骨折。
结果：老年女性的尿酸水平较高，高BMI,糖尿病,还有高血压.还观察到更高水平的PTH和血清钙，但对维生素D无影响。血清尿酸与光密度和超声参数呈正相关，与椎体骨折呈负相关。
结论：在研究的绝经后妇女人群中，sUA水平与BMD相关，BUA,和QUI-刚度，这种相关性与年龄和BMI无关。此外,sUA与椎体骨折减少有关。这些结果暗示了sUA对骨代谢的有益影响，具有定量和定性的积极作用，反映在椎骨骨折的患病率较低。
