Abstract：
Organisms are usually exposed to mixtures of emerging pollutants in aquatic environments. Due to their widespread use and environmental relevance, the individual and combined effects of the drugs azithromycin (AZT) and ivermectin (IVM) on the freshwater rotifer Lecane papuana and the euryhaline rotifer Proales similis were investigated. Rotifers showed greater sensitivity to IVM compared to AZT. The LC50 values of IVM and AZT for L. papuana and P. similis were 0.163 and 0.172 mg/L, and 13.52 and 20.00 mg/L, respectively. Population growth rates, assessed in chronic toxicity assays, responded negatively to increasing concentrations of both toxicants, either individually or in combination. Our results revealed two distinct combined toxicity responses: a strong synergistic effect in the freshwater rotifer and a marked antagonistic impact of the AZT-IVM mixtures in the euryhaline rotifer.
摘要：
生物通常暴露于水生环境中新兴污染物的混合物。由于它们的广泛使用和环境相关性，研究了阿奇霉素（AZT）和伊维菌素（IVM）对淡水轮虫Lecanepapuana和euryhaline轮虫Proales的单独和联合作用。与AZT相比，轮虫对IVM的敏感性更高。IVM和AZT对木瓜乳杆菌和木瓜的LC50值分别为0.163和0.172mg/L，13.52和20.00毫克/升，分别。人口增长率,在慢性毒性试验中评估，对两种毒物浓度的增加做出了负面反应，无论是单独或组合。我们的结果揭示了两种不同的组合毒性反应：在淡水轮虫中具有很强的协同作用，而AZT-IVM混合物在欧陆轮虫中具有明显的拮抗作用。
