Abstract：
Approaches for the induction of neurogenesis and neuronal recovery through several modalities are gaining popularity in Parkinson\'s disease (PD). Growth hormone (GH) seems to have a role in the reversal of neural function following brain injury as well as in normal brain development and function; therefore, the use of GH may represent a feasible strategy in the management of PD. This experimental study aimed to evaluate the effect of growth hormone on motor function and dendrite morphology in rats with 6-hydroxydopamine (6-OHDA)-induced PD model. Thirty-six Sprague Dawley rats were included and randomly allocated into one of the six study groups: two controls and four treatment groups that received daily subcutaneous growth hormone injections for 21 days, 1, 2, and 3 months. PD model was induced through unilateral 6-OHDA injection to the nigrostriatal pathway. The following assessments were made: apomorphine rotation test, stepping test, and tissue examinations for tyrosine hydroxylase and dendrite morphology. The apomorphine rotation test and the stepping test confirmed the presence of PD. These tests as well as dendritic spine density/number and length assessments showed improvement in PD findings over time with GH administration. Findings of this study suggest that GH administration may improve dendrite morphology and motor function in the PD model, which may translate into symptom relief and quality of life improvement in patients with PD. Such potential benefits should be tested in robust clinical studies.
摘要：
通过几种方式诱导神经发生和神经元恢复的方法在帕金森病（PD）中越来越受欢迎。生长激素（GH）似乎在脑损伤后的神经功能逆转以及正常的大脑发育和功能中起作用；因此，GH的使用可能是PD管理的可行策略。本实验旨在评价生长激素对6-羟基多巴胺(6-OHDA)诱导的PD模型大鼠运动功能和树突形态的影响。纳入36只SpragueDawley大鼠，并随机分为六个研究组之一：两个对照组和四个治疗组，每天接受皮下生长激素注射21天，1、2和3个月。通过向黑质纹状体途径单侧注射6-OHDA诱导PD模型。进行了以下评估：阿朴吗啡旋转试验，步进测试,和组织检查酪氨酸羟化酶和树突形态。阿朴吗啡旋转试验和步进试验证实了PD的存在。这些测试以及树突棘密度/数量和长度评估显示,随着GH施用,PD发现随时间的改善。这项研究的结果表明，GH给药可以改善PD模型中的树突形态和运动功能，这可能转化为PD患者的症状缓解和生活质量改善。这种潜在的好处应该在强有力的临床研究中进行测试。
