Abstract：
OBJECTIVE: To analyze the overall long-term outcome of surgically treated skull base and temporal bone chondrosarcomas.
METHODS: The medical records of patients with surgically treated skull base and temporal bone chondrosarcomas between 1983 and 2024 were thoroughly evaluated.
RESULTS: Out of a total of over 5000 skull base surgeries performed at our center, only 29 patients had histopathologically confirmed chondrosarcomas of the skull base and temporal bone. The mean of patients age was 45.6, and the male-to-female ratio was 1.9:1. The most common symptoms included hearing loss (58.6%), tinnitus (41.4%), diplopia (31%), dysphonia (24.1%), dysphagia (20.7%), vertigo (10.3%), and dizziness (10.3%). The most frequent locations of lesions among the 29 patients are as follows: petroclival region (34.5%), jugular foramen (27.6%), petrous apex (17.2%), middle ear (13.8%), others (3.4%). TO, IFTA, IFTB, IFTC, POTS, and combined surgical approaches were commonly used. The rate of gross total removal and recurrence was 82.6% and 13.8% respectively. The follow-up duration of 6 patients was more than five years and less than ten years whereas ten patients had more than ten years of follow-up.
CONCLUSIONS: Chondrosarcoma of the skull base and temporal bone is a very rare pathology. Due to its multiple potential sites of origin and histological specificity, it presents us with significant challenges. Gross total removal is the primary treatment for chondrosarcoma of the skull base and temporal bone. Personalized decision-making should be considered based on the following aspects: tumor, patient, and surgeon\'s factors. Postoperative radiation therapy is complementary to surgical treatment in grades II and III lesions to achieve long-term survival.
METHODS: The medical records of patients with surgically treated skull base and temporal bone chondrosarcomas between 1983 and 2024 were thoroughly evaluated.
RESULTS: Out of a total of over 5000 skull base surgeries performed at our center, only 29 patients had histopathologically confirmed chondrosarcomas of the skull base and temporal bone. The mean of patients age was 45.6, and the male-to-female ratio was 1.9:1. The most common symptoms included hearing loss (58.6%), tinnitus (41.4%), diplopia (31%), dysphonia (24.1%), dysphagia (20.7%), vertigo (10.3%), and dizziness (10.3%). The most frequent locations of lesions among the 29 patients are as follows: petroclival region (34.5%), jugular foramen (27.6%), petrous apex (17.2%), middle ear (13.8%), others (3.4%). TO, IFTA, IFTB, IFTC, POTS, and combined surgical approaches were commonly used. The rate of gross total removal and recurrence was 82.6% and 13.8% respectively. The follow-up duration of 6 patients was more than five years and less than ten years whereas ten patients had more than ten years of follow-up.
CONCLUSIONS: Chondrosarcoma of the skull base and temporal bone is a very rare pathology. Due to its multiple potential sites of origin and histological specificity, it presents us with significant challenges. Gross total removal is the primary treatment for chondrosarcoma of the skull base and temporal bone. Personalized decision-making should be considered based on the following aspects: tumor, patient, and surgeon\'s factors. Postoperative radiation therapy is complementary to surgical treatment in grades II and III lesions to achieve long-term survival.
摘要：
目的：分析经手术治疗的颅底和颞骨软骨肉瘤的总体长期预后。
方法：彻底评估了1983年至2024年间手术治疗的颅底和颞骨软骨肉瘤患者的病历。
结果：在我们中心进行的5000多次颅底手术中，只有29例患者经组织病理学证实为颅底和颞骨软骨肉瘤。患者的平均年龄为45.6岁，男女比例为1.9：1。最常见的症状包括听力损失（58.6%），耳鸣（41.4%），复视（31%），发音困难（24.1%），吞咽困难（20.7%），眩晕(10.3%)，和头晕(10.3%)。29例患者中最常见的病变位置如下：岩斜区域（34.5％），颈静脉孔（27.6%），岩尖（17.2%），中耳(13.8%),其他（3.4%）。TO,IFTA,IFTB,IFTC,POTS,和联合手术方法是常用的。总清除率和复发率分别为82.6%和13.8%。6例患者的随访时间超过5年，少于10年，而10例患者的随访时间超过10年。
结论：颅底和颞骨软骨肉瘤是一种非常罕见的病理。由于其多个潜在的起源和组织学特异性，它给我们带来了巨大的挑战。总切除是颅底和颞骨软骨肉瘤的主要治疗方法。个性化决策应基于以下几个方面来考虑：肿瘤，病人,和外科医生的因素。术后放射治疗是II级和III级病变手术治疗的补充，以实现长期生存。
方法：彻底评估了1983年至2024年间手术治疗的颅底和颞骨软骨肉瘤患者的病历。
结果：在我们中心进行的5000多次颅底手术中，只有29例患者经组织病理学证实为颅底和颞骨软骨肉瘤。患者的平均年龄为45.6岁，男女比例为1.9：1。最常见的症状包括听力损失（58.6%），耳鸣（41.4%），复视（31%），发音困难（24.1%），吞咽困难（20.7%），眩晕(10.3%)，和头晕(10.3%)。29例患者中最常见的病变位置如下：岩斜区域（34.5％），颈静脉孔（27.6%），岩尖（17.2%），中耳(13.8%),其他（3.4%）。TO,IFTA,IFTB,IFTC,POTS,和联合手术方法是常用的。总清除率和复发率分别为82.6%和13.8%。6例患者的随访时间超过5年，少于10年，而10例患者的随访时间超过10年。
结论：颅底和颞骨软骨肉瘤是一种非常罕见的病理。由于其多个潜在的起源和组织学特异性，它给我们带来了巨大的挑战。总切除是颅底和颞骨软骨肉瘤的主要治疗方法。个性化决策应基于以下几个方面来考虑：肿瘤，病人,和外科医生的因素。术后放射治疗是II级和III级病变手术治疗的补充，以实现长期生存。
