Abstract：
Paraneoplastic glomerular disease (PGD) develops from tumor cell products, leading to renal dysfunction. Unlike direct tumor effects, PGD illustrates the complex association between cancer and diverse clinical presentations and outcomes. Initially detected in a Hodgkin\'s disease patient, current research has defined diagnostic criteria based on PGD symptoms and cancer progression. PGDs, although rare (found in <1% of adult cancer patients with overt renal manifestations), are crucial, as they can signal cancer onset and frequently resist standard glomerulonephritis treatments. The emerging field of onconephrology studies this relationship between kidney disorders and cancers. The exact cause of many PGD cases remains unknown. This review examines PGDs, their clinicopathological features, related cancers, and mechanisms, emphasizing the need for early diagnosis and tailored treatment for kidney disease and linked cancer.
摘要：
副肿瘤肾小球疾病（PGD）由肿瘤细胞产物发展而来，导致肾功能不全.与直接的肿瘤效应不同,PGD说明了癌症与不同临床表现和结果之间的复杂关联。最初在霍奇金病患者中发现，目前的研究已经根据PGD症状和癌症进展确定了诊断标准.PGD,虽然罕见（发现在<1％的成人癌症患者明显的肾脏表现），是至关重要的,因为它们可以预示癌症的发作，并且经常抵抗标准的肾小球肾炎治疗。新兴的眼科研究肾脏疾病和癌症之间的这种关系。许多PGD病例的确切原因仍然未知。这篇综述研究了PGD，他们的临床病理特征，相关癌症,和机制，强调肾脏疾病和相关癌症的早期诊断和定制治疗的必要性。
