Abstract：
OBJECTIVE: This study aimed to investigate health-related quality of life (HRQoL), sexual function, psychological-health, reproductive concerns, and fertility outcomes of women of reproductive age undergoing Fertility-Sparing Surgery (FSS) for treatment of ovarian cancer (OC) or borderline ovarian tumor (BOT), over a 2-year period.
METHODS: Prospective longitudinal multicentre study including women 18-40 years undergoing FSS between 2016 and 2018 in Sweden. Clinical data at diagnosis, histopathological findings and 2-year follow-up regarding oncological and reproductive outcomes were collected. Participants completed the EORTC QLQ-C30 and OV-28, FSFI, HADS and study-specific items at time of diagnosis and at one- and two-years following FSS. Data were analysed using a model for repeated measures to investigate changes over time.
RESULTS: Of 68 eligible women, 49 were included following exclusions due to benign pathology or subsequent radical surgery. During a mean follow-up of 20.5 months, two women experienced a recurrence and 82% reported regular menstruations. The majority (94%) had a strong desire to become biological mothers, which remained or increased over time. The conception-rate was 76%. HRQoL, psychological-health and sexual function improved over time and the proportion of women with sexual dysfunction decreased. At one-year follow-up 50% of nulliparous women had scores indicating sexual dysfunction compared to 0% of the women who had given birth either before or after surgery (p = 0.008).
CONCLUSIONS: HRQoL, psychological-health and sexual function improved during two-year follow-up after FSS in young women presenting with OC or BOT. Women who had given birth prior to or after FSS reported improved sexual function compared to nulliparous women.
METHODS: Prospective longitudinal multicentre study including women 18-40 years undergoing FSS between 2016 and 2018 in Sweden. Clinical data at diagnosis, histopathological findings and 2-year follow-up regarding oncological and reproductive outcomes were collected. Participants completed the EORTC QLQ-C30 and OV-28, FSFI, HADS and study-specific items at time of diagnosis and at one- and two-years following FSS. Data were analysed using a model for repeated measures to investigate changes over time.
RESULTS: Of 68 eligible women, 49 were included following exclusions due to benign pathology or subsequent radical surgery. During a mean follow-up of 20.5 months, two women experienced a recurrence and 82% reported regular menstruations. The majority (94%) had a strong desire to become biological mothers, which remained or increased over time. The conception-rate was 76%. HRQoL, psychological-health and sexual function improved over time and the proportion of women with sexual dysfunction decreased. At one-year follow-up 50% of nulliparous women had scores indicating sexual dysfunction compared to 0% of the women who had given birth either before or after surgery (p = 0.008).
CONCLUSIONS: HRQoL, psychological-health and sexual function improved during two-year follow-up after FSS in young women presenting with OC or BOT. Women who had given birth prior to or after FSS reported improved sexual function compared to nulliparous women.
摘要：
目的：本研究旨在调查健康相关生活质量（HRQoL），性功能,心理健康,生殖问题，和生育结果的育龄妇女进行生育保留手术（FSS）治疗卵巢癌（OC）或交界性卵巢肿瘤（BOT），在2年期间。
方法：前瞻性纵向多中心研究，包括2016年至2018年在瑞典接受FSS的18-40岁女性。诊断时的临床数据，我们收集了有关肿瘤和生殖结局的组织病理学结果和2年随访.参与者完成了EORTCQLQ-C30和OV-28，FSFI，诊断时以及FSS后一年和两年的HADS和研究特异性项目。使用重复测量模型分析数据，以调查随时间的变化。
结果：在68名符合条件的女性中，由于良性病理或随后的根治性手术而排除后，包括49例。在平均20.5个月的随访中，两名女性出现复发,82%报告有规律月经.大多数（94％）有强烈的愿望成为亲生母亲，随着时间的推移而保持或增加。受孕率为76%。HRQoL,随着时间的推移,心理健康和性功能得到改善,性功能障碍女性比例下降.在一年的随访中，50％的未产妇女的得分表明性功能障碍，而手术前或手术后分娩的妇女的得分为0％（p=0.008）。
结论：HRQoL，出现OC或BOT的年轻女性在FSS后的两年随访中，心理健康和性功能得到改善。与未分娩妇女相比，在FSS之前或之后分娩的妇女报告性功能改善。
方法：前瞻性纵向多中心研究，包括2016年至2018年在瑞典接受FSS的18-40岁女性。诊断时的临床数据，我们收集了有关肿瘤和生殖结局的组织病理学结果和2年随访.参与者完成了EORTCQLQ-C30和OV-28，FSFI，诊断时以及FSS后一年和两年的HADS和研究特异性项目。使用重复测量模型分析数据，以调查随时间的变化。
结果：在68名符合条件的女性中，由于良性病理或随后的根治性手术而排除后，包括49例。在平均20.5个月的随访中，两名女性出现复发,82%报告有规律月经.大多数（94％）有强烈的愿望成为亲生母亲，随着时间的推移而保持或增加。受孕率为76%。HRQoL,随着时间的推移,心理健康和性功能得到改善,性功能障碍女性比例下降.在一年的随访中，50％的未产妇女的得分表明性功能障碍，而手术前或手术后分娩的妇女的得分为0％（p=0.008）。
结论：HRQoL，出现OC或BOT的年轻女性在FSS后的两年随访中，心理健康和性功能得到改善。与未分娩妇女相比，在FSS之前或之后分娩的妇女报告性功能改善。
