PAK 和 Hippo 途径抑制剂组合在 NF2 缺陷型神经鞘瘤中的协同作用。
Mesh : Humans Neurilemmoma / metabolism genetics pathology p21-Activated Kinases / metabolism antagonists & inhibitors genetics Cell Proliferation / drug effects Hippo Signaling Pathway Neurofibromin 2 / genetics deficiency metabolism Signal Transduction / drug effects Protein Serine-Threonine Kinases / metabolism genetics antagonists & inhibitors Cell Line, Tumor Transcription Factors / metabolism genetics Apoptosis / drug effects Drug Synergism Neurofibromatosis 2 / metabolism genetics YAP-Signaling Proteins / metabolism genetics Protein Kinase Inhibitors / pharmacology Adaptor Proteins, Signal Transducing / metabolism genetics DNA-Binding Proteins / metabolism genetics
来 源:
DOI:10.1371/journal.pone.0305121
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