Abstract：
In this study, oil-in-water nanoemulsions are prepared, an isotropic mixture of oil, surfactant, and cosurfactants. The nanoemulsions exhibit stable structures and are capable of efficiently encapsulating hydrophobic drugs such as doxorubicin (Dox). Compared to polymeric micelles, nanoemulsions demonstrate enhanced stability and loading capacity for Dox. Furthermore, nanoemulsions release Dox steadily over 14 days, with 51.6% released within the initial 24 h and up to 80% over the subsequent period. These properties suggest that nanoemulsions can mitigate the side effects related to the burst release of Dox, thereby improving therapeutic efficacy and safety. Additionally, nanoemulsion-treated cardiomyocytes show increased viability compared to those treated with free Dox, indicating the potential of nanoemulsions to alleviate Dox-induced cardiotoxicity. Overall, nanoemulsions hold promise as versatile and efficient drug carriers for improving cancer treatment outcomes.
摘要：
在这项研究中,制备水包油纳米乳液，各向同性的油混合物，表面活性剂，和助表面活性剂。纳米乳剂表现出稳定的结构并且能够有效地包封疏水性药物如多柔比星(Dox)。与聚合物胶束相比，纳米乳液对Dox表现出增强的稳定性和负载能力。此外，纳米乳液在14天内稳定释放Dox，在最初的24小时内释放了51.6%，在随后的时期释放了高达80%。这些特性表明，纳米乳液可以减轻与Dox爆发释放相关的副作用，从而提高治疗效果和安全性。此外,与用游离Dox处理的心肌细胞相比，纳米乳液处理的心肌细胞显示出增加的活力，表明纳米乳剂减轻Dox诱导的心脏毒性的潜力。总的来说,纳米乳剂有望成为改善癌症治疗结果的多功能和有效的药物载体。
