PDF(Pubmed)
Abstract：
OBJECTIVE: Feline calicivirus (FCV)-associated viral systemic disease (VSD) is a severe systemic disease caused by virulent FCV strains and has a very poor prognosis.
OBJECTIVE: To evaluate the clinical characteristics of a nosocomial FCV-VSD outbreak involving 18 cats in Korea.
METHODS: Medical records of cats diagnosed with FCV-VSD from March to September 2018 at a referral veterinary hospital were reviewed. The patient\'s signalment, history, clinical features, diagnosis, treatment, and prognosis were evaluated.
RESULTS: Two outbreaks involving 18 cats diagnosed with FCV-VSD occurred over a 6-month period at a referral hospital in Korea. Anorexia, lethargy, fever, and limb edema were the most commonly observed clinical symptoms. Lymphopenia and macrothrombocytopenia were the most common hematological findings, and hyperbilirubinemia and increased levels of aspartate aminotransferase, creatine kinase, and serum amyloid A were the most frequent results of serum biochemistry. FCV was detected by reverse transcription polymerase chain reaction in 11 patients and the remaining 7 were suspected with FCV-VSD. The overall mortality rate was 72.2%. The hospital was closed and disinfected twice, and no additional outbreaks have occurred since the last patient.
CONCLUSIONS: The clinical and diagnostic characteristics and outcomes of FCV-VSD described in this study can be used to recognize and contain infectious diseases through quick action. To the best of the authors\' knowledge, this is the first report of a nosocomial outbreak of FCV-VSD in Asia.
OBJECTIVE: To evaluate the clinical characteristics of a nosocomial FCV-VSD outbreak involving 18 cats in Korea.
METHODS: Medical records of cats diagnosed with FCV-VSD from March to September 2018 at a referral veterinary hospital were reviewed. The patient\'s signalment, history, clinical features, diagnosis, treatment, and prognosis were evaluated.
RESULTS: Two outbreaks involving 18 cats diagnosed with FCV-VSD occurred over a 6-month period at a referral hospital in Korea. Anorexia, lethargy, fever, and limb edema were the most commonly observed clinical symptoms. Lymphopenia and macrothrombocytopenia were the most common hematological findings, and hyperbilirubinemia and increased levels of aspartate aminotransferase, creatine kinase, and serum amyloid A were the most frequent results of serum biochemistry. FCV was detected by reverse transcription polymerase chain reaction in 11 patients and the remaining 7 were suspected with FCV-VSD. The overall mortality rate was 72.2%. The hospital was closed and disinfected twice, and no additional outbreaks have occurred since the last patient.
CONCLUSIONS: The clinical and diagnostic characteristics and outcomes of FCV-VSD described in this study can be used to recognize and contain infectious diseases through quick action. To the best of the authors\' knowledge, this is the first report of a nosocomial outbreak of FCV-VSD in Asia.
摘要：
目的：猫杯状病毒（FCV）相关的病毒性全身性疾病（VSD）是由FCV毒株引起的严重的全身性疾病，预后极差。
目的：评估韩国18只猫的医院FCV-VSD暴发的临床特征。
方法：回顾了2018年3月至9月在转诊兽医医院诊断为FCV-VSD的猫的病历。病人的信号，历史,临床特征,诊断,治疗,并对预后进行评估。
结果：韩国一家转诊医院在6个月内发生了两次暴发，涉及18只被诊断为FCV-VSD的猫。厌食症,嗜睡,发烧,肢体水肿是最常见的临床症状。淋巴细胞减少和大型血小板减少是最常见的血液学结果，高胆红素血症和天冬氨酸转氨酶水平升高，肌酸激酶，血清淀粉样蛋白A是最常见的血清生化结果。通过逆转录聚合酶链反应在11例患者中检测到FCV，其余7例怀疑患有FCV-VSD。总死亡率为72.2%。医院关闭并消毒了两次，自最后一名患者以来，没有发生其他疫情。
结论：本研究中描述的FCV-VSD的临床和诊断特征以及结果可用于通过快速行动识别和控制感染性疾病。据作者所知，这是亚洲FCV-VSD医院内爆发的首例报告.
目的：评估韩国18只猫的医院FCV-VSD暴发的临床特征。
方法：回顾了2018年3月至9月在转诊兽医医院诊断为FCV-VSD的猫的病历。病人的信号，历史,临床特征,诊断,治疗,并对预后进行评估。
结果：韩国一家转诊医院在6个月内发生了两次暴发，涉及18只被诊断为FCV-VSD的猫。厌食症,嗜睡,发烧,肢体水肿是最常见的临床症状。淋巴细胞减少和大型血小板减少是最常见的血液学结果，高胆红素血症和天冬氨酸转氨酶水平升高，肌酸激酶，血清淀粉样蛋白A是最常见的血清生化结果。通过逆转录聚合酶链反应在11例患者中检测到FCV，其余7例怀疑患有FCV-VSD。总死亡率为72.2%。医院关闭并消毒了两次，自最后一名患者以来，没有发生其他疫情。
结论：本研究中描述的FCV-VSD的临床和诊断特征以及结果可用于通过快速行动识别和控制感染性疾病。据作者所知，这是亚洲FCV-VSD医院内爆发的首例报告.
