Abstract：
Alpha T-catenin has recently been identified as a crucial tumor suppressor in various cancer types, with roles that go beyond just providing structural support in adherens junctions. This review brings together recent findings on alpha T-catenin\'s important involvement in key signaling pathways related to cancer progression. We present strong evidence of its regulatory role in Wnt signaling, a pathway often disrupted in colorectal cancer, and explain how it inhibits cell proliferation and tumor growth. We also discuss the significant downregulation of alpha T-catenin in colorectal cancers and its potential as a prognostic marker. Moreover, this review looks at how increasing alpha T-catenin levels can reduce tumor growth and spread, suggesting new therapeutic strategies. Additionally, we reveal alpha T-catenin\'s unexpected impact on NF-κB signaling in basal E-cadherin-negative breast cancer, expanding its importance across different cancer types. By bringing these findings together, we provide a thorough understanding of alpha T-catenin\'s tumor-suppressing actions, setting the stage for new targeted therapies and diagnostic tools in cancer treatment.
摘要：
AlphaT-catenin最近被确定为各种癌症类型的关键肿瘤抑制因子，角色不仅仅是在附着者的连接处提供结构支持。这篇综述汇集了关于αT-catenin在与癌症进展相关的关键信号通路中的重要参与的最新发现。我们提供了其在Wnt信号传导中的调节作用的有力证据，在结直肠癌中经常被破坏的通路，并解释它如何抑制细胞增殖和肿瘤生长。我们还讨论了结直肠癌中αT-catenin的显着下调及其作为预后标志物的潜力。此外，这篇综述着眼于增加αT-catenin水平如何减少肿瘤生长和扩散，提出新的治疗策略。此外,我们揭示了αT-catenin对基底E-cadherin阴性乳腺癌中NF-κB信号的意外影响，在不同的癌症类型中扩展其重要性。通过将这些发现汇集在一起，我们提供了对αT-catenin的肿瘤抑制作用的透彻理解，为癌症治疗中的新靶向疗法和诊断工具奠定了基础。
