Abstract：
BACKGROUND: Schizophrenia is a severe and chronic neuropsychiatric disorder that involves profound impairment of psychopathology in cognition, emotion, perception, and other aspects of behavior. Factors, such as the nature of the disease, length of hospital stay, duration of illness, and side effects of psychotropic drugs, may contribute to poor oral health and the risk of developing bruxism in patients with schizophrenia.
OBJECTIVE: To evaluate the prevalence of bruxism and associated factors in patients with schizophrenia.
METHODS: This cross-sectional study was conducted in a single center with 211 patients with schizophrenia. Study participants were graded according to \"probable\" bruxism based on positive clinical inspection, with or without a positive self-report. The type of antipsychotic treatment used in participants was evaluated in three categories: typical antipsychotic monotherapy, atypical antipsychotic monotherapy, and a combination of both. Binary logistic regression models were used to evaluate associations between probable bruxism and different factors.
RESULTS: The mean age of the study participants was 51.02 ± 9.29 years, and 112 (52.5%) were males. Probable bruxism was identified in 87 (41.2%) of the study participants. Younger age (AOR = 0.88, 95% CI = 0.838-0.928, P < 0.001), higher duration of illness (AOR = 1.50, 95% CI = 1.278-7.545, P < 0.001), and combination antipsychotic therapy (AOR = 3.042, 95% CI = 1.278-7.545, P = 0.015) were significant factors associated with probable bruxism among patients with schizophrenia on treatment.
CONCLUSIONS: The relatively high prevalence of probable bruxism in patients with schizophrenia and its relation to antipsychotics was observed. There is a need for more research on the causes and treatment of bruxism in schizophrenia.
OBJECTIVE: To evaluate the prevalence of bruxism and associated factors in patients with schizophrenia.
METHODS: This cross-sectional study was conducted in a single center with 211 patients with schizophrenia. Study participants were graded according to \"probable\" bruxism based on positive clinical inspection, with or without a positive self-report. The type of antipsychotic treatment used in participants was evaluated in three categories: typical antipsychotic monotherapy, atypical antipsychotic monotherapy, and a combination of both. Binary logistic regression models were used to evaluate associations between probable bruxism and different factors.
RESULTS: The mean age of the study participants was 51.02 ± 9.29 years, and 112 (52.5%) were males. Probable bruxism was identified in 87 (41.2%) of the study participants. Younger age (AOR = 0.88, 95% CI = 0.838-0.928, P < 0.001), higher duration of illness (AOR = 1.50, 95% CI = 1.278-7.545, P < 0.001), and combination antipsychotic therapy (AOR = 3.042, 95% CI = 1.278-7.545, P = 0.015) were significant factors associated with probable bruxism among patients with schizophrenia on treatment.
CONCLUSIONS: The relatively high prevalence of probable bruxism in patients with schizophrenia and its relation to antipsychotics was observed. There is a need for more research on the causes and treatment of bruxism in schizophrenia.
摘要：
背景：精神分裂症是一种严重的慢性神经精神障碍，涉及认知中精神病理学的严重损害，情感，感知，和其他方面的行为。因素，比如疾病的性质，住院时间,疾病的持续时间,以及精神药物的副作用，可能导致精神分裂症患者口腔健康状况不佳和患磨牙症的风险。
目的：评估精神分裂症患者磨牙症的患病率及相关因素。
方法：这项横断面研究是在一个单中心对211名精神分裂症患者进行的。研究参与者根据阳性临床检查根据“可能的磨牙症”进行分级，有或没有积极的自我报告。参与者使用的抗精神病药物治疗类型分为三类：典型的抗精神病药物单一疗法，非典型抗精神病药物单一疗法，以及两者的结合。二元逻辑回归模型用于评估可能的磨牙症与不同因素之间的关联。
结果：研究参与者的平均年龄为51.02±9.29岁，男性112人(52.5%)。在87名（41.2%）的研究参与者中发现了可能的磨牙症。年龄较小(AOR=0.88,95%CI=0.838-0.928,P<0.001),病程延长(AOR=1.50,95%CI=1.278-7.545,P<0.001),和联合抗精神病药物治疗（AOR=3.042，95％CI=1.278-7.545，P=0.015）是精神分裂症患者可能发生磨牙症的重要因素。
结论：观察到精神分裂症患者可能磨牙症的患病率及其与抗精神病药物的关系相对较高。有必要对精神分裂症磨牙症的原因和治疗进行更多的研究。
目的：评估精神分裂症患者磨牙症的患病率及相关因素。
方法：这项横断面研究是在一个单中心对211名精神分裂症患者进行的。研究参与者根据阳性临床检查根据“可能的磨牙症”进行分级，有或没有积极的自我报告。参与者使用的抗精神病药物治疗类型分为三类：典型的抗精神病药物单一疗法，非典型抗精神病药物单一疗法，以及两者的结合。二元逻辑回归模型用于评估可能的磨牙症与不同因素之间的关联。
结果：研究参与者的平均年龄为51.02±9.29岁，男性112人(52.5%)。在87名（41.2%）的研究参与者中发现了可能的磨牙症。年龄较小(AOR=0.88,95%CI=0.838-0.928,P<0.001),病程延长(AOR=1.50,95%CI=1.278-7.545,P<0.001),和联合抗精神病药物治疗（AOR=3.042，95％CI=1.278-7.545，P=0.015）是精神分裂症患者可能发生磨牙症的重要因素。
结论：观察到精神分裂症患者可能磨牙症的患病率及其与抗精神病药物的关系相对较高。有必要对精神分裂症磨牙症的原因和治疗进行更多的研究。
