Abstract：
The Zika virus (ZIKV) epidemic in Latin America (2015-2016) has primarily been studied in urban centers, with less understanding of its impact on smaller rural communities. To address this gap, we analyzed ZIKV sero-epidemiology in six rural Ecuadorian communities (2018-2019) with varying access to a commercial hub. Seroprevalence ranged from 19% to 54% measured by NS1 blockade of binding ELISA. We observed a decline in ZIKV seroprevalence between 2018 and 2019 that was greater among younger populations, suggesting that the attack rates in the 2015-16 epidemic were significantly higher than our 2018 observations. These data indicate that the 2015-16 epidemic included significant transmission in rural and more remote settings. Our observations of high seroprevalence in our area of study highlights the importance of surveillance and research in rural areas lacking robust health systems to manage future Zika outbreaks and vaccine initiatives.
摘要：
寨卡病毒（ZIKV）在拉丁美洲的流行（2015-2016）主要在城市中心进行了研究，对其对较小农村社区的影响了解较少。为了解决这个差距，我们分析了厄瓜多尔6个农村社区(2018-2019年)的ZIKV血清流行病学,这些社区有不同的商业中心.通过NS1阻断结合ELISA测量的血清阳性率范围为19%至54%。我们观察到ZIKV血清阳性率在2018年至2019年间下降，在年轻人群中下降幅度更大。这表明2015-16年疫情的发病率明显高于我们2018年的观察结果。这些数据表明，2015-16年的流行病包括在农村和更偏远地区的重大传播。我们对研究领域高血清阳性率的观察强调了在缺乏强大卫生系统的农村地区进行监测和研究的重要性，以管理未来的寨卡病毒暴发和疫苗计划。
