OBJECTIVE: To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU.
METHODS: The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method.
RESULTS: Although the serum zonulin value of the patients was higher compared to the controls, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, p=0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group (p=0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls.
CONCLUSIONS: This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.
目的:通过检测CSU患者血清中连蛋白水平,评价CSU与肠通透性的相关性。
方法:该研究包括60例诊断为CSU的患者和64例年龄和性别匹配的健康个体作为对照。使用ELISA方法测定血清zonulin的水平。
结果:尽管患者的血清zonulin值高于对照组,差异未达到显着水平(24.65±8.49ng/ml与21.03±7.36ng/ml,p=0.077)。CSU组血清zonulin水平与荨麻疹活动评分有显著相关性(p=0.013)。当前研究的结果表明,CSU患者和健康对照组之间的血清zonulin值显着不同。
结论:这项研究对于首次调查CSU中的血清zonulin水平非常重要。然而,有必要对更大的患者群体进行进一步的研究.