PDF(Pubmed)
Abstract：
BACKGROUND: There have been reports indicating a correlation between heightened intestinal permeability and many autoimmune and chronic inflammatory disorders. The involvement of autoimmunity is now recognized as a significant factor in the development of chronic spontaneous urticaria (CSU). Zonulin is an important biomarker that regulates tight junction permeability within cells in the gastrointestinal tract, hence facilitating intestinal permeability.
OBJECTIVE: To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU.
METHODS: The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method.
RESULTS: Although the serum zonulin value of the patients was higher compared to the controls, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, p=0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group (p=0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls.
CONCLUSIONS: This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.
OBJECTIVE: To evaluate the correlation of CSU with intestinal permeability by measuring the serum levels of zonulin in patients diagnosed with CSU.
METHODS: The study included 60 patients diagnosed with CSU and 64 age- and sex-matched healthy individuals as controls. Levels of serum zonulin were determined using the ELISA method.
RESULTS: Although the serum zonulin value of the patients was higher compared to the controls, the difference did not reach a significant level (24.65±8.49 ng/ml vs. 21.03±7.36 ng/ml, p=0.077). The serum zonulin level had a significant correlation with the urticaria activity score in the CSU group (p=0.013). The results of the current study revealed that serum zonulin values significantly differed between patients with CSU and healthy controls.
CONCLUSIONS: This study is important in terms of being the first to investigate the serum zonulin levels in CSU. However, there is a need for further studies with larger patient groups.
摘要：
背景：有报道表明肠道通透性升高与许多自身免疫性和慢性炎症性疾病之间存在相关性。现在，自身免疫的参与被认为是慢性自发性荨麻疹（CSU）发展的重要因素。Zonulin是一种重要的生物标志物，可调节胃肠道细胞内的紧密连接通透性，从而促进肠道通透性。
目的：通过检测CSU患者血清中连蛋白水平，评价CSU与肠通透性的相关性。
方法：该研究包括60例诊断为CSU的患者和64例年龄和性别匹配的健康个体作为对照。使用ELISA方法测定血清zonulin的水平。
结果：尽管患者的血清zonulin值高于对照组，差异未达到显着水平（24.65±8.49ng/ml与21.03±7.36ng/ml，p=0.077)。CSU组血清zonulin水平与荨麻疹活动评分有显著相关性(p=0.013)。当前研究的结果表明，CSU患者和健康对照组之间的血清zonulin值显着不同。
结论：这项研究对于首次调查CSU中的血清zonulin水平非常重要。然而,有必要对更大的患者群体进行进一步的研究.
目的：通过检测CSU患者血清中连蛋白水平，评价CSU与肠通透性的相关性。
方法：该研究包括60例诊断为CSU的患者和64例年龄和性别匹配的健康个体作为对照。使用ELISA方法测定血清zonulin的水平。
结果：尽管患者的血清zonulin值高于对照组，差异未达到显着水平（24.65±8.49ng/ml与21.03±7.36ng/ml，p=0.077)。CSU组血清zonulin水平与荨麻疹活动评分有显著相关性(p=0.013)。当前研究的结果表明，CSU患者和健康对照组之间的血清zonulin值显着不同。
结论：这项研究对于首次调查CSU中的血清zonulin水平非常重要。然而,有必要对更大的患者群体进行进一步的研究.
