Abstract：
Reid, Ly-Anh, Jordan L Rees, Miranda Kimber, Marina James, Graeme M Purdy, Megan Smorschok, Lauren E Maier, Normand G. Boulé, Trevor A. Day, Margie H. Davenport, and Craig D. Steinback. Blood glucose during high altitude trekking in young healthy adults. High Alt Med Biol. 00:00-00, 2024. Introduction: High altitude trekking is becoming more popular and accessible to an increased number of people. Simultaneously, there is a worldwide rise in the prevalence of metabolic diseases. The purpose of this study was to examine the impact of a gradual trekking ascent to high altitude on continuous glucose monitoring outcomes including fasting, mean 24-hour, postprandial, and post-75 g modified oral glucose tolerance test. This study also investigated the relationship between physical activity intensity, high altitude, and glucose concentrations. Methods: Individuals (n = 9) from Alberta, Canada participated in a 2-week trek in the Khumbu Valley in Nepal, ascending by foot from 2,860 m to 5,300 m (∼65 km) over 10 days. A standardized 75 g oral glucose load was given to participants at four different altitudes (1,130 m, 3,440 m, 3,820 m, 5,160 m). Physical activity (Actigraph accelerometry) and interstitial glucose (iPro2, Medtronic) were measured continuously during the trek. Results: Fasting and mean 24-hour glucose concentrations were not different between altitudes. However, 2-hour post dinner glucose and 2-hour post lunch glucose, AUC concentrations were different between altitudes. The relationship between physical activity intensity and glucose was not influenced by increasing altitudes. Conclusion: Our findings suggest that glucose regulation is largely preserved at high altitude; however, inconsistency in our postprandial glucose concentrations at altitude warrants further investigation.
摘要：
里德,Ly-Anh,JordanLRees,米兰达·金伯,玛丽娜·詹姆斯,GraemeMPurdy,MeganSmorschok,LaurenEMaier,NormandG.Boulé,特雷弗·戴，玛吉·H·达文波特,还有CraigD.Steinback.年轻健康成年人在高海拔徒步旅行期间的血糖。高AltMedBiol。00:00-00,2024.简介：高海拔徒步旅行变得越来越流行，越来越多的人可以使用。同时,代谢性疾病的患病率在全球范围内上升。这项研究的目的是研究逐渐徒步旅行到高海拔对连续血糖监测结果的影响，包括禁食，平均24小时，餐后,和后75克改进的口服葡萄糖耐量试验。这项研究还调查了身体活动强度之间的关系，高海拔,和葡萄糖浓度。方法：来自艾伯塔省的个人(n=9)，加拿大参加了在尼泊尔昆布山谷为期2周的跋涉,在10天内从2,860米步行上升到5,300米(~65公里)。在四个不同的海拔高度（1,130m，3,440m,3,820米，5,160米）。在跋涉过程中连续测量身体活动（Actigraph加速度计）和间质葡萄糖（iPro2，Medtronic）。结果：海拔之间的空腹和平均24小时葡萄糖浓度没有差异。然而,晚餐后2小时葡萄糖和午餐后2小时葡萄糖，不同海拔高度的AUC浓度不同。身体活动强度与葡萄糖之间的关系不受海拔高度增加的影响。结论：我们的发现表明，在高海拔地区，血糖调节在很大程度上得以保留；然而，我们在海拔地区餐后葡萄糖浓度的不一致值得进一步调查.
