UNASSIGNED: A meta-analysis using case-control studies was performed to assess the diagnostic performance of LFA alone or galactomannan (GM) combined with LFA (GM-LFA) as screening tests for IA. The sensitivity, specificity, and summary receiver operating characteristic curves were constructed.
UNASSIGNED: Nineteen studies with 2838 patients were included. The pooled effect sizes for different indicators included: sensitivity (77 % for LFA and 75 % for GM-LFA), specificity (88 % for LFA and 87 % for GM-LFA), positive likelihood ratio (6.65 for LFA and 12.02 for GM-LFA), negative likelihood ratio (0.26 for LFA and 0.27 for GM-LFA), and the diagnostic odds ratio (25.81 for LFA and 44.87 for GM-LFA). The area under the curve was 0.91 for LFA and 0.94 for GM-LFA with a cut-off value ≥ 0.5.
UNASSIGNED: The present meta-analysis suggested that LFA or GM-LFA at an optical density index (ODI) cutoff of ≥0.5 was a useful diagnostic tool for IA in patients. The results showed no significant differences in the accuracy of LFA alone and GM-LFA in diagnosing IA. In the clinical diagnosis and treatment of IA, LFA can be recommended if timely results are needed.
■使用病例对照研究进行了荟萃分析,以评估单独的LFA或半乳甘露聚糖(GM)联合LFA(GM-LFA)作为IA筛查测试的诊断性能。敏感性,特异性,并构建了概括的接受者工作特性曲线。
■纳入了2838例患者的19项研究。不同指标的合并效应大小包括:敏感性(LFA为77%,GM-LFA为75%),特异性(LFA为88%,GM-LFA为87%),正似然比(LFA为6.65,GM-LFA为12.02),负似然比(LFA为0.26,GM-LFA为0.27),和诊断比值比(LFA为25.81,GM-LFA为44.87)。LFA的曲线下面积为0.91,GM-LFA的曲线下面积为0.94,临界值≥0.5。
■本荟萃分析表明,光密度指数(ODI)临界值≥0.5的LFA或GM-LFA是患者IA的有用诊断工具。结果表明,单独使用LFA和GM-LFA诊断IA的准确性没有显着差异。在IA的临床诊断和治疗中,如果需要及时的结果,可以推荐LFA。