PDF(Pubmed)
Abstract：
UNASSIGNED: Efficient diagnosis of patients at high risk for invasive aspergillosis (IA) improves the outcome of the disease. Lateral flow assay (LFA) is a novel technology and assessing its diagnostic accuracy is of great significance in the clinical management of IA.
UNASSIGNED: A meta-analysis using case-control studies was performed to assess the diagnostic performance of LFA alone or galactomannan (GM) combined with LFA (GM-LFA) as screening tests for IA. The sensitivity, specificity, and summary receiver operating characteristic curves were constructed.
UNASSIGNED: Nineteen studies with 2838 patients were included. The pooled effect sizes for different indicators included: sensitivity (77 % for LFA and 75 % for GM-LFA), specificity (88 % for LFA and 87 % for GM-LFA), positive likelihood ratio (6.65 for LFA and 12.02 for GM-LFA), negative likelihood ratio (0.26 for LFA and 0.27 for GM-LFA), and the diagnostic odds ratio (25.81 for LFA and 44.87 for GM-LFA). The area under the curve was 0.91 for LFA and 0.94 for GM-LFA with a cut-off value ≥ 0.5.
UNASSIGNED: The present meta-analysis suggested that LFA or GM-LFA at an optical density index (ODI) cutoff of ≥0.5 was a useful diagnostic tool for IA in patients. The results showed no significant differences in the accuracy of LFA alone and GM-LFA in diagnosing IA. In the clinical diagnosis and treatment of IA, LFA can be recommended if timely results are needed.
UNASSIGNED: A meta-analysis using case-control studies was performed to assess the diagnostic performance of LFA alone or galactomannan (GM) combined with LFA (GM-LFA) as screening tests for IA. The sensitivity, specificity, and summary receiver operating characteristic curves were constructed.
UNASSIGNED: Nineteen studies with 2838 patients were included. The pooled effect sizes for different indicators included: sensitivity (77 % for LFA and 75 % for GM-LFA), specificity (88 % for LFA and 87 % for GM-LFA), positive likelihood ratio (6.65 for LFA and 12.02 for GM-LFA), negative likelihood ratio (0.26 for LFA and 0.27 for GM-LFA), and the diagnostic odds ratio (25.81 for LFA and 44.87 for GM-LFA). The area under the curve was 0.91 for LFA and 0.94 for GM-LFA with a cut-off value ≥ 0.5.
UNASSIGNED: The present meta-analysis suggested that LFA or GM-LFA at an optical density index (ODI) cutoff of ≥0.5 was a useful diagnostic tool for IA in patients. The results showed no significant differences in the accuracy of LFA alone and GM-LFA in diagnosing IA. In the clinical diagnosis and treatment of IA, LFA can be recommended if timely results are needed.
摘要：
■对侵袭性曲霉病（IA）高风险患者的有效诊断可改善疾病的预后。侧流分析（LFA）是一项新技术，评估其诊断准确性在IA的临床管理中具有重要意义。
■使用病例对照研究进行了荟萃分析，以评估单独的LFA或半乳甘露聚糖（GM）联合LFA（GM-LFA）作为IA筛查测试的诊断性能。敏感性,特异性，并构建了概括的接受者工作特性曲线。
■纳入了2838例患者的19项研究。不同指标的合并效应大小包括：敏感性(LFA为77%，GM-LFA为75%)，特异性（LFA为88%，GM-LFA为87%），正似然比(LFA为6.65，GM-LFA为12.02)，负似然比(LFA为0.26，GM-LFA为0.27)，和诊断比值比（LFA为25.81，GM-LFA为44.87）。LFA的曲线下面积为0.91，GM-LFA的曲线下面积为0.94，临界值≥0.5。
■本荟萃分析表明，光密度指数（ODI）临界值≥0.5的LFA或GM-LFA是患者IA的有用诊断工具。结果表明，单独使用LFA和GM-LFA诊断IA的准确性没有显着差异。在IA的临床诊断和治疗中，如果需要及时的结果，可以推荐LFA。
■使用病例对照研究进行了荟萃分析，以评估单独的LFA或半乳甘露聚糖（GM）联合LFA（GM-LFA）作为IA筛查测试的诊断性能。敏感性,特异性，并构建了概括的接受者工作特性曲线。
■纳入了2838例患者的19项研究。不同指标的合并效应大小包括：敏感性(LFA为77%，GM-LFA为75%)，特异性（LFA为88%，GM-LFA为87%），正似然比(LFA为6.65，GM-LFA为12.02)，负似然比(LFA为0.26，GM-LFA为0.27)，和诊断比值比（LFA为25.81，GM-LFA为44.87）。LFA的曲线下面积为0.91，GM-LFA的曲线下面积为0.94，临界值≥0.5。
■本荟萃分析表明，光密度指数（ODI）临界值≥0.5的LFA或GM-LFA是患者IA的有用诊断工具。结果表明，单独使用LFA和GM-LFA诊断IA的准确性没有显着差异。在IA的临床诊断和治疗中，如果需要及时的结果，可以推荐LFA。
