PDF(Pubmed)
Abstract：
Rhino-orbital-cerebral mucormycosis (ROCM) is a rare, invasive, and fatal fungal disease that is often easily misdiagnosed in the early stages due to the lack of specific clinical manifestations and adequate auxiliary examinations. Early diagnosis and timely therapy are essential for successful treatment. In this report, we presented a 46-year-old man with diabetes who experienced gradual vision loss, right ptosis, swelling, and headaches that progressively worsened to death within 4 days after admission. It was finally confirmed as a fungal Rhizopus arrhizus infection by metagenomics next-generation sequencing (mNGS). Our report has proved that mNGS testing should be strongly recommended in highly suspected patients.
摘要：
犀眶-大脑毛霉菌病（ROCM）是一种罕见的，侵入性,和致命的真菌病，由于缺乏特异性的临床表现和充分的辅助检查，往往在早期容易误诊。早期诊断和及时治疗对于成功治疗至关重要。在这份报告中,我们介绍了一名46岁的糖尿病患者，他的视力逐渐下降，右上眼睑,肿胀,和头痛在入院后4天内逐渐恶化至死亡。最终通过宏基因组学下一代测序（mNGS）确认为真菌根霉感染。我们的报告证明，应强烈建议对高度怀疑的患者进行mNGS测试。
