PDF(Pubmed)
Abstract：
BACKGROUND: Prediabetes is defined as a hyperglycemic state between normal glucose metabolism and diabetes mellitus. It is also recognized as a predisposing factor for cardiovascular disease. Apolipoprotein is a constituent of lipoproteins, and its ratio levels (ApoB/ApoA1 ratio) are considered an independent risk factor for cardiovascular diseases. This study aimed to evaluate the apolipoprotein ratio (ApoB/ApoA1 ratio) and lipoprotein ratio (low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio) in prediabetes in relation to glycemic levels and establish the association between apolipoprotein and lipoprotein ratios in prediabetic individuals and their glycemic levels.
METHODS: A case-control study was conducted among 150 participants, 75 with prediabetes and 75 apparently healthy individuals (with no prediabetes or diabetes), from January 1, 2023 to December 30, 2023. The parameters involved are fasting serum glucose, insulin, blood HbA1c%, HDL-C, LDL-C, apolipoprotein A, apolipoprotein B, and lipoprotein(a) (Lp(a)), measured using different principles.
RESULTS: Prediabetes was more predominant in males (58.7%), particularly those aged over 40 years (74.7%). The mean Lp(a) (46.18±11.66 mg/dl), LDL-C/HDL-C ratio (1.74±0.96), and ApoB/ApoA ratio (1.10±0.62) were significantly higher among prediabetic individuals. Moreover, these ratios were insignificantly higher in prediabetic individuals with HbA1c level (5.8-6.4%) and fasting glucose level (100-125 mg/dl) than those with lower levels.
CONCLUSIONS: Prediabetic individuals exhibited a notably elevated average level of Lp(a), as well as increased mean ApoB/ApoA1 ratio and mean LDL-C/HDL-C ratio compared to individuals who were apparently healthy.
METHODS: A case-control study was conducted among 150 participants, 75 with prediabetes and 75 apparently healthy individuals (with no prediabetes or diabetes), from January 1, 2023 to December 30, 2023. The parameters involved are fasting serum glucose, insulin, blood HbA1c%, HDL-C, LDL-C, apolipoprotein A, apolipoprotein B, and lipoprotein(a) (Lp(a)), measured using different principles.
RESULTS: Prediabetes was more predominant in males (58.7%), particularly those aged over 40 years (74.7%). The mean Lp(a) (46.18±11.66 mg/dl), LDL-C/HDL-C ratio (1.74±0.96), and ApoB/ApoA ratio (1.10±0.62) were significantly higher among prediabetic individuals. Moreover, these ratios were insignificantly higher in prediabetic individuals with HbA1c level (5.8-6.4%) and fasting glucose level (100-125 mg/dl) than those with lower levels.
CONCLUSIONS: Prediabetic individuals exhibited a notably elevated average level of Lp(a), as well as increased mean ApoB/ApoA1 ratio and mean LDL-C/HDL-C ratio compared to individuals who were apparently healthy.
摘要：
背景：糖尿病前期定义为正常葡萄糖代谢和糖尿病之间的高血糖状态。它也被认为是心血管疾病的诱发因素。载脂蛋白是脂蛋白的一个组成部分，其比值(ApoB/ApoA1比值)被认为是心血管疾病的独立危险因素。本研究旨在评估糖尿病前期患者载脂蛋白比率（ApoB/ApoA1比率）和脂蛋白比率（低密度脂蛋白胆固醇/高密度脂蛋白胆固醇（LDL-C/HDL-C）比率）与血糖水平的关系，并建立糖尿病前期患者载脂蛋白和脂蛋白比率与其血糖水平之间的关系。
方法：对150名参与者进行了病例对照研究，75名糖尿病前期患者和75名明显健康的个体（没有糖尿病前期或糖尿病），从2023年1月1日至2023年12月30日。涉及的参数是空腹血清葡萄糖，胰岛素，血HbA1c%,HDL-C,LDL-C,载脂蛋白A,载脂蛋白B,和脂蛋白（a）（Lp（a）），用不同的原理测量。
结果：糖尿病前期在男性中更为明显（58.7％），特别是40岁以上的人(74.7%)。平均Lp(a)(46.18±11.66mg/dl)，LDL-C/HDL-C比值（1.74±0.96），在糖尿病前期个体中，ApoB/ApoA比值（1.10±0.62）明显较高。此外，在HbA1c水平(5.8-6.4%)和空腹血糖水平(100-125mg/dl)的糖尿病前期个体中,这些比率明显高于较低水平的个体.
结论：糖尿病前期个体表现出显著升高的Lp(a)平均水平，以及与明显健康的个体相比，平均ApoB/ApoA1比值和平均LDL-C/HDL-C比值增加。
方法：对150名参与者进行了病例对照研究，75名糖尿病前期患者和75名明显健康的个体（没有糖尿病前期或糖尿病），从2023年1月1日至2023年12月30日。涉及的参数是空腹血清葡萄糖，胰岛素，血HbA1c%,HDL-C,LDL-C,载脂蛋白A,载脂蛋白B,和脂蛋白（a）（Lp（a）），用不同的原理测量。
结果：糖尿病前期在男性中更为明显（58.7％），特别是40岁以上的人(74.7%)。平均Lp(a)(46.18±11.66mg/dl)，LDL-C/HDL-C比值（1.74±0.96），在糖尿病前期个体中，ApoB/ApoA比值（1.10±0.62）明显较高。此外，在HbA1c水平(5.8-6.4%)和空腹血糖水平(100-125mg/dl)的糖尿病前期个体中,这些比率明显高于较低水平的个体.
结论：糖尿病前期个体表现出显著升高的Lp(a)平均水平，以及与明显健康的个体相比，平均ApoB/ApoA1比值和平均LDL-C/HDL-C比值增加。
