Abstract：
The condition commonly referred to as long coronavirus disease (COVID) is characterized by the continuation of symptoms, sometimes accompanied by new symptoms that persist after the resolution of acute coronavirus disease 2019 (COVID-19). This observational cross-sectional study investigated 332 patients with long COVID in the Brazilian Amazon region. The study aimed to elucidate the systemic interactions associated with long COVID by compiling the findings related to hematological, coagulation, immunological, metabolic, hepatic, renal, and muscular profiles. Participants with long COVID were identified using rigorous criteria and underwent thorough laboratory examinations. The obtained data were subsequently analyzed, allowing for comparisons, associations, and correlations between findings within distinct groups in the study. Significant associations were observed between hospitalization during the acute phase and persistent laboratory abnormalities, suggesting a potential link between acute severity and long-term effects. Notably, individuals with long COVID for over a year exhibited elevated levels of monocytes, prolonged prothrombin times, reduced prothrombin activity, high levels of lactate dehydrogenase, and an increased frequency of qualitative C-reactive protein detection. This study provides valuable insights into the laboratory risk profile of patients with long COVID, particularly in the unique context of the Amazon region, where patients exhibit persistent symptoms lasting up to 1261 days.
摘要：
这种通常被称为长冠状病毒病(COVID)的疾病的特征是症状持续，有时伴有新的症状，这些症状在2019年急性冠状病毒病（COVID-19）解决后仍然存在。这项观察性横断面研究调查了巴西亚马逊地区332例长COVID患者。该研究旨在通过汇编与血液学相关的发现来阐明与长COVID相关的全身相互作用，凝血,免疫学，新陈代谢，肝，肾,和肌肉轮廓。使用严格的标准鉴定患有长期COVID的参与者，并进行了全面的实验室检查。随后对获得的数据进行了分析，允许比较，协会,以及研究中不同群体的发现之间的相关性。在急性期住院和持续的实验室异常之间观察到显着的关联，提示急性严重程度和长期影响之间的潜在联系。值得注意的是,长COVID一年以上的个体表现出单核细胞水平升高，延长凝血酶原时间，凝血酶原活性降低，高水平的乳酸脱氢酶,和定性C反应蛋白检测的频率增加。这项研究为长期COVID患者的实验室风险状况提供了有价值的见解，特别是在亚马逊地区的独特背景下，其中患者表现出持续的症状持续1261天。
