Abstract：
In medical practice, iodine contrast media are necessary for diagnostic techniques. However, it comes with a potential risk to the patient in the form of allergic reactions. The aim of this research is to study the effects of iodine contrast media on endothelial cells in an in vitro system at various concentrations, specifically investigating their impact on cell viability, cell cycle, and apoptosis in the treated cells within the field of diagnostic radiology. Our results showed that in iodine contrast media, when the concentration was within the range of 2.5-50 mgI/ml, cell viability decreased by 50%. Conversely, exposure to ioversol at concentrations between 12.5 and 50.0 mgI/ml resulted in a notable increase in the percentage of total apoptotic cells, including both early and late apoptosis. In conclusion, our in vitro investigation sheds light on the effect of iodinated contrast media on endothelial cell viability, cell cycle progression, and apoptosis. These findings contribute valuable insights to ensure the safety of their use, aligning with guidelines in radiological procedures. Further research and adherence to established guidelines are crucial for refining our understanding and promoting the safe application of iodinated contrast media in the field of radiology.
摘要：
在医疗实践中,碘造影剂是诊断技术所必需的。然而,它以过敏反应的形式给患者带来潜在的风险。本研究的目的是研究不同浓度的碘造影剂对体外系统中内皮细胞的影响，专门研究它们对细胞活力的影响，细胞周期,和诊断放射学领域内治疗细胞的凋亡。我们的结果表明，在碘造影剂中，当浓度在2.5-50mgI/ml范围内时，细胞活力下降了50%。相反，暴露于浓度在12.5和50.0mgI/ml之间的ioversol导致总凋亡细胞百分比显着增加，包括早期和晚期细胞凋亡。总之,我们的体外研究揭示了碘化造影剂对内皮细胞活力的影响，细胞周期进程，和凋亡。这些发现为确保其使用安全提供了宝贵的见解，与放射学程序指南保持一致。进一步研究和遵守既定指南对于完善我们的理解和促进碘化造影剂在放射学领域的安全应用至关重要。
