Abstract：
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), new variants with enhanced transmissibility and pathogenicity have surfaced. The World Health Organization has designated five such variants-Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529)-as variants of concern. Each variant exhibits distinct characteristics, with many displaying a combination of point mutations and insertions/deletions (indels). These genetic alterations, including mutations, recombinations, and rearrangements, contribute to the emergence of new strains that may exhibit modified phenotypes. However, identifying recombinant forms can be challenging due to their resemblance to other lineages. It is critical to monitor the evolution of new recombinant variants, particularly in light of the potential for vaccine-resistant strains and their accelerated propagation. Recombination has played a pivotal role in the development of certain SARS-CoV-2 variants, such as XA, XD, XF, XE, and XBB, among others. This report delves into the significance of recombination in the evolution of SARS-CoV-2 variants, especially Omicron sublineages, underscoring the necessity for continuous surveillance of the SARS-CoV-2 genome to identify newly emerged recombinant variants.
摘要：
自从严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）出现以来，具有增强的传播性和致病性的新变体已经浮出水面。世界卫生组织（WHO）指定了五个这样的变体-Alpha（B.1.1.7），Beta(B.1.351),Gamma(P.1),Delta(B.1.617.2),和Omicron（B.1.1.529）-作为关注变量（VOC）。每个变体都表现出不同的特征，许多显示点突变和插入/缺失(indel)的组合。这些基因改变，包括突变,重组,和重新安排，有助于出现可能表现出修饰表型的新菌株。然而,鉴定重组形式可能是具有挑战性的，因为它们与其他谱系相似。监测新的重组变体的进化至关重要，特别是考虑到疫苗抗性菌株的潜力及其加速传播。重组在某些SARS-CoV-2变体的发展中起着关键作用，比如XA,XD,XF,XE,XBB,在其他人中。本报告深入研究了重组在SARS-CoV-2变体进化中的意义，尤其是Omicron亚谱系，强调连续监测SARS-CoV-2基因组以鉴定新出现的重组变体的必要性。
